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FLASH GENE
Symbol SCA8 contributors: mct/npt - updated : 05/11/2008
Corresponding disease
SCA8 spinocerebellar ataxia 8
Location 13q21      Physical location : -
Genatlas name spinocerebellar ataxia 8
Synonym name see ATXN8OS
DNA
TYPE functioning gene
SPECIAL FEATURE overlapping, gene in gene, opposite orientation, antisens
text antisense transcript to KLHL1 producing no protein
STRUCTURE 32.00 kb     5 Exon(s)
motif repetitive sequence   triplet
text structure a non coding CTG repeat preceded by a polymorphic but stable CTA tract (1-21)
MAPPING cloned Y linked   status provisional
RNA
TRANSCRIPTS type messenger
text transcripts containing the SCA8 CUG repeat tract are alternatively spliced and polyadenylated (Nemes, 2000)
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrainhindbraincerebellum  
Respiratorylung    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervouscentral   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
HOMOLOGY
Homologene
FAMILY
CATEGORY unknown/unspecified
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm
basic FUNCTION
  • untranslated RNA functioning as a gene regulator
  • CELLULAR PROCESS cell life, differentiation
    cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binding
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SCA8
    Susceptibility
    Variant & Polymorphism repeat CTG trinucleotide repeat expansion
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS