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FLASH GENE
Symbol SBSN contributors: SGE/npt - updated : 23-03-2010
HGNC name suprabasin
HGNC id 24950
Location 19q13.12      Physical location : 36.014.269 - 36.019.253
Synonym name likely ortholog of mouse epidermal differentiation protein suprabasin
Synonym symbol(s) UNQ698, MGC75533, HLAR698
DNA
TYPE functioning gene
STRUCTURE 4.98 kb     5 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 978 - 247 - Park (2002)
  • isoform 2, precursor
  • - - 1998 - 590 - Park (2002)
  • isoform 1, precursor
  • - - 744 - 169 - Park (2002)
  • isoform 3, precursor
  • EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus    
    Lymphoid/Immunethymus    
    Reproductivefemale systemuterus   
    Skin/Tegumentskin   specific
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier liningepidermisstratum spinosum 
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Skin/Tegumentkeratinocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a functional secretory signal
  • an amino-terminal domain
  • a central domain composed of repeats rich in glycine and alanine
  • a carboxyl-terminal domain
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION extracellular
    text secreted protein
    basic FUNCTION
  • potentially playing a role in the process of epidermal differentiation (Park 2002)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • substrate for transglutaminase 2 and 3 activity
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS