basic FUNCTION
| transcriptional regulator functioning as a "landing platform" for several chromatin remodelling enzymes and hence regulating large chromatin domain |
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first cell-type-specific transcription factor of a novel type that functions as a regulator of the transcription of large chromatin domains |
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targeting chromatin remodelling to regulate genes over long distances |
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providing a novel nuclear structure that functions as a tissue-specific organizer of DNA sequences and regulating tissue-specific nuclear architecture and gene expression |
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organizes cell type-specific nuclear architecture by anchoring specialized DNA sequences and recruiting chromatin remodeling factors to control gene transcription |
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required not only for compacting chromatin into dense loops at the 200-kb cytokine locus but also for inducing IL4, IL5, IL13 and MAF expression |
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transcriptional regulator controlling the gene expression that is essential in the maturation of the immune T-cell |
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regulates gene expression by acting as a "docking site" for several chromatin remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters |
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participates in the maintenance of chromatin architecture by organizing it into distinct loops via periodic tethering of matrix attachment regions (MARs) to the nuclear matrix |
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MAR-binding protein, found to regulate beta-like globin genes through chromatin remodeling |
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regulates beta-globin cluster through linking nuclear architecture, chromatin structure and functional organization of DNA sequences |
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involved in organizing higher-order chromatin structure, including the subnuclear organization of individual genes within multigene clusters |
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essential for proper facial patterning of the embryo and for normal bone development |
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function of SATB1 and SATB2 is critically required for the proper differentiation of ES cells into somatic cells |
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direct downstream target of TP63, contributing in epidermal morphogenesis via establishing tissue-specific chromatin organization and gene expression in epidermal progenitor cells |
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plays potentially a critical role in cortical neurons to facilitate neuronal plasticity |
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SATB1, SATB2 proteins promote trophoblast stem cell renewal and inhibit differentiation |
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mediates Wnt signaling by recruiting CTNNB1 to its genomic targets and coordinates T helper type 2 (T(H)2) differentiation by positively regulating GATA3 |
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novel role of SATB1 in cell type-specific regulation of replication timing along the chromosome |
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IKZF2 and SATB1, are considered to be important in proper Treg development |
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is a regulator that promotes hematopoietic stem cells quiescence and represses lineage commitment |
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coordinates gene expression of progenitor cells by functioning as a genome organizer |