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FLASH GENE
Symbol SAT1 contributors: npt/ - updated : 14/11/2008
HGNC name spermidine/spermine N1-acetyltransferase 1
HGNC id 10540
Corresponding disease
DUPXP chromosome Xp duplications
KFSD keratosis follicularis spinulosa decalvans
Location Xp22.11      Physical location : 23.801.274 - 23.804.325
Synonym name
  • putrescine acetyltransferase
  • polyamine N-acetyltransferase 1
  • diamine acetyltransferase 1
  • spermidine/spermine N1-acetyltransferase alpha
  • Synonym symbol(s) SSAT, ATDA, SAT, DC21, SSAT-1
    EC.number 2.3.1.57
    DNA
    TYPE functioning gene
    STRUCTURE 3.02 kb     6 Exon(s)
    regulatory sequence Binding site   HRE
    text structure
  • binding of Sp1 to the GC-box located 42 to 51 bp upstream from the transcription start site
  • a polyamine-responsive element
  • MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 1089 19.9 171 - -
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivepharynx   highly
     salivary gland   moderately
    Hearing/Equilibriumear   moderately
    Lymphoid/Immunespleen   moderately
    Reproductivefemale systemovary  highly
    Visualeyeanterior segment   
    cell lineage
    cell lines
    fluid/secretion highly in blood
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer homomer , tetramer
    HOMOLOGY
    interspecies homolog to rattus Sat1 (96.5 pc)
    homolog to murine Sat1 (96.5 pc)
    Homologene
    FAMILY
  • acetyltransferase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    text colocalized with SLC3A2
    basic FUNCTION
  • involved in the regulation of polyamine transport out of cells
  • catalyzing the N(1)-acetylation of spermidine and spermine and, by the successive activity of polyamine oxidase, spermine can be converted to spermidine and spermidine to putrescine
  • acting as an acyltransferase
  • may facilitate excretion of acetylated polyamines
  • functioning as a cardioprotectant under ATP-depleted conditions
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism amine
    signaling
    being a rate-limiting enzyme in the catabolic pathway of polyamine metabolism
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with SLC3A2
  • SAT1 has been reported to exert other effects in cells by its interaction with other cellular proteins, but EIF5A is the first target protein specifically acetylated by SAT1
  • cell & other
    REGULATION
    induced by ischemia
    AMPK signaling
    inhibited by K-RAS (negatively regulates SLC3A2 and SAT1 expression)
    ASSOCIATED DISORDERS
    corresponding disease(s) KFSD , DUPXP
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS