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FLASH GENE

Symbol

SART3

contributors: mct - updated : 17/09/2008

HGNC name	squamous cell carcinoma antigen recognized by T cells 3
HGNC id	16860

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	DSAP1 porokeratosis, disseminated superficial actinic, 1
Location	12q24.1      Physical location : 108.915.990 - 108.955.165
Synonym name	Prp24 related protein
	tat-interacting protein of 110 kDa
Synonym symbol(s)	TIP110, KIAA0156, p110(nrb), RP11-13G14, P100, p110, DSAP1, MGC138188

DNA

TYPE	functioning gene
STRUCTURE	39.20 kb     19 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

Physical map

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed SART3 19 - 4377 109.8 963 - -

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly Hearing/Equilibrium ear inner cochlea   highly Reproductive female system uterus cervix   highly   male system testis       Respiratory respiratory tract larynx     highly Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal

cell lineage
cell lines	squamous cell carcinoma (head and neck, lung, esophageal), adenocarcinoma
fluid/secretion

at STAGE

physiological period

fetal

Text	pancreas, liver

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	eight HAT repeats
	two C-terminal RNA recognition motif (RRM) domains
	two nuclear localization signals
	a putative tyrosine phosphorylation motif
	an RGD cell attachment sequence

conjugated

Other

mono polymer

complex

HOMOLOGY

interspecies	homolog to dog SART3 (91.6 pc)
	homolog to chimpanzee SART3 (99.8 pc)
	homolog to rattus Sart3 (86.8 pc)
	homolog to murine Sart3 (87.3 pc)

Homologene

FAMILY

RNP ELAV family

CATEGORY

regulatory , antigen

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
text	undetectable in the nucleus of any cell lines of nonmalignant cells or normal tissues, except for the testis
	expressed in the cytoplasm of all the proliferating cells, including normal and malignant cells, but not in normal tissues, except for the testis and the fetal liver

basic FUNCTION	may be involved in the regulation of mRNA splicing
	required for the proper development and maintenance of neurons presumably by affecting RNA metabolism
	tumor rejection antigen capable of inducing HLA-24-restricted and tumor specific cytotoxic T lymphocytes
	could be an appropriate vaccine candidate for specific immunotherapy for colorectal carcinoma patients
	regulating Tat transactivation activity
	negative regulator of androgen receptor transcriptional activation and may be directly involved in AR-related developmental, physiological and pathological processes

CELLULAR PROCESS

nucleotide, RNA splicing

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component	component of the 7SK snRNP complex at least composed of P-TEFb (composed of CDK9 and CCNT1/cyclin-T1), HEXIM1, HEXIM2, BCDIN3, SART3 proteins and 7SK and U6 snRNAs
	acetylation

INTERACTION

DNA

RNA

binding

small molecule

protein	interacting with RNPS1
	binding to HIV-1 Tat

cell & other

REGULATION

Other

phosphorylated upon DNA damage, probably by ATM or ATR

ASSOCIATED DISORDERS

corresponding disease(s)

DSAP1

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS