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FLASH GENE
Symbol SART3 contributors: mct - updated : 17/09/2008
HGNC name squamous cell carcinoma antigen recognized by T cells 3
HGNC id 16860
Corresponding disease
DSAP1 porokeratosis, disseminated superficial actinic, 1
Location 12q24.1      Physical location : 108.915.990 - 108.955.165
Synonym name
  • Prp24 related protein
  • tat-interacting protein of 110 kDa
  • Synonym symbol(s) TIP110, KIAA0156, p110(nrb), RP11-13G14, P100, p110, DSAP1, MGC138188
    DNA
    TYPE functioning gene
    STRUCTURE 39.20 kb     19 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    hSyn 12q24.11 brain synembryn LOC390356 12 similar to translation elongation factor eEF-1 beta chain - rabbit MGC17943 12q24.11 hypothetical protein MGC17943 LOC80298 12q24.1 transcription termination factor-like protein CRY1 12q23-q24.1 cryptochrome 1 (photolyase-like) LOC390357 12 similar to Cca3 protein BTBD11 12q24.11 BTB (POZ) domain containing 11 PWP1 12q24.11 nuclear phosphoprotein similar to S. cerevisiae PWP1 PRDM4 12q23-q24.1 PR domain containing 4 ASCL4 12q24.11 class II bHLH protein ASCL4 LOC390358 12 similar to RET finger protein-like 3 LOC390359 12 similar to programmed cell death 2 isoform 2; zinc finger protein Rp-8; programmed cell death 2/Rp8 homolog KIAA0789 12q24.11 similar to programmed cell death 2 isoform 2; zinc finger protein Rp-8; programmed cell death 2/Rp8 homolog LOC196469 12q24.11 similar to apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G; phorbolin-like protein MDS019 CMKLR1 12q24.1 chemokine-like receptor 1 HYPE 12q24.1 chemokine-like receptor 1 SART3 12q24.1 squamous cell carcinoma antigen recognised by T cells 3 NIFU 12-q24.1 squamous cell carcinoma antigen recognised by T cells 3 LOC338773 12q24.12 hypothetical protein LOC338773 SELPLG 12q24 selectin P ligand CORO1C 12q24.1 coronin, actin binding protein, 1C SSH1 12q24.12 slingshot 1 DAO 12q24.12 D-amino-acid oxidase DKFZp761H039 12q24.12 hypothetical protein DKFZp761H039 USP30 12q23.3 ubiquitin specific protease 30 LOC121642 12q24.12 similar to hypothetical protein 9530023G02 UNG 12q23-q24.1 uracil-DNA glycosylase LOC387883 12 LOC387883 ACACB 12q24.1 acetyl-Coenzyme A carboxylase beta FOXN4 12q24.12 forkhead box N4 LOC387884 12 LOC387884 FLJ37587 12q24.12 hypothetical protein FLJ37587 KCTD10 12q24.12 potassium channel tetramerisation domain containing 10 UBE3B 12q24.12 potassium channel tetramerisation domain containing 10 MMAB MVK 12q24 mevalonate kinase (mevalonic aciduria) MGC14436 12q24.12 hypothetical protein MGC14436 FLJ14721 12q24.12 hypothetical protein FLJ14721 TRPV4 12q24.1 transient receptor potential cation channel, subfamily V, member 4 GLTP 12q24.12 glycolipid transfer protein MGC10854 12q24.12 hypothetical protein MGC10854 GIT2 12q24.1 G protein-coupled receptor kinase-interactor 2 ANKRD13 12q24.12 ankyrin repeat domain 13 LOC144705 12q24.12 hypothetical gene supported by AF086409 CDV-1 12q24.13 carnitine deficiency-associated gene expressed in ventricle 1 ATP2A2 12q24.1 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 HMGA1L3 12q24.13 high mobility group AT-hook 1-like 3 ARPC3 12q24 actin related protein 2/3 complex, subunit 3, 21kDa
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    19 - 4377 109.8 963 - -
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Hearing/Equilibriumearinnercochlea highly
    Reproductivefemale systemuteruscervix highly
     male systemtestis   
    Respiratoryrespiratory tractlarynx  highly
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines squamous cell carcinoma (head and neck, lung, esophageal), adenocarcinoma
    fluid/secretion
    at STAGE
    physiological period fetal
    Text pancreas, liver
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • eight HAT repeats
  • two C-terminal RNA recognition motif (RRM) domains
  • two nuclear localization signals
  • a putative tyrosine phosphorylation motif
  • an RGD cell attachment sequence
  • conjugated Other
    mono polymer complex
    HOMOLOGY
    interspecies homolog to dog SART3 (91.6 pc)
    homolog to chimpanzee SART3 (99.8 pc)
    homolog to rattus Sart3 (86.8 pc)
    homolog to murine Sart3 (87.3 pc)
    Homologene
    FAMILY
  • RNP ELAV family
  • CATEGORY regulatory , antigen
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    text
  • undetectable in the nucleus of any cell lines of nonmalignant cells or normal tissues, except for the testis
  • expressed in the cytoplasm of all the proliferating cells, including normal and malignant cells, but not in normal tissues, except for the testis and the fetal liver
  • basic FUNCTION
  • may be involved in the regulation of mRNA splicing
  • required for the proper development and maintenance of neurons presumably by affecting RNA metabolism
  • tumor rejection antigen capable of inducing HLA-24-restricted and tumor specific cytotoxic T lymphocytes
  • could be an appropriate vaccine candidate for specific immunotherapy for colorectal carcinoma patients
  • regulating Tat transactivation activity
  • negative regulator of androgen receptor transcriptional activation and may be directly involved in AR-related developmental, physiological and pathological processes
  • CELLULAR PROCESS nucleotide, RNA splicing
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the 7SK snRNP complex at least composed of P-TEFb (composed of CDK9 and CCNT1/cyclin-T1), HEXIM1, HEXIM2, BCDIN3, SART3 proteins and 7SK and U6 snRNAs
  • acetylation
  • INTERACTION
    DNA
    RNA binding
    small molecule
    protein
  • interacting with RNPS1
  • binding to HIV-1 Tat
  • cell & other
    REGULATION
    Other phosphorylated upon DNA damage, probably by ATM or ATR
    ASSOCIATED DISORDERS
    corresponding disease(s) DSAP1
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS