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FLASH GENE
Symbol SART1 contributors: mct - updated : 07-03-2012
HGNC name squamous cell carcinoma antigen recognised by T cells
HGNC id 10538
Location 11q13.2      Physical location : 65.729.159 - 65.747.606
Synonym name U4/U6.U5 tri-snRNP-associated 110 kDa protein
Synonym symbol(s) ARA1, HOMS1, SART1259, SNu66
DNA
TYPE functioning gene
STRUCTURE 18.45 kb     20 Exon(s)    single Copie(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Map cen - D11S913 - SART1 - D11S97 - D11S916 - qter
Authors Wheatley (02)
Physical map
RELA 11q13 v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65 (avian) SIPA1 11q13.3 signal-induced proliferation-associated gene 1 LOC387782 11 LOC387782 HTATIP 11q13 HIV-1 Tat interactive protein, 60kDa AYP1 11q13.1 AYP1 protein LOC390211 11 similar to Keratin, type II cytoskeletal 8 (Cytokeratin 8) (K8) (CK 8) LOC91056 11q13.1 hypothetical protein BC004895 OVOL1 11q13 ovo-like 1(Drosophila) FLJ30934 11q13.1 hypothetical protein FLJ30934 CFL1 11q13 cofilin 1 (non-muscle) MUS81 11q13 MUS81 endonuclease homolog (yeast) EFEMP2 11q13 EGF-containing fibulin-like extracellular matrix protein 2 CTSW 11q13.1 cathepsin W (lymphopain) FIBP 11q13.1 fibroblast growth factor (acidic) intracellular binding protein DIPA 11q12.1 hepatitis delta antigen-interacting protein A FOSL1 11q13 FOS-like antigen 1 P5326 11q13.1 hypothetical protein p5326 DRAP1 11q13.3 DR1-associated protein 1 (negative cofactor 2 alpha) FLJ32880 11q13.1 hypothetical protein FLJ32880 SART1 11q12-q13 squamous cell carcinoma antigen recognised by T cells MGC11102 11q13.1 hypothetical protein MGC11102 BANF1 11q13.1 barrier to autointegration factor 1 CST6 11q13.2 cystatin E/M CATSPER1 11q12.1 cation channel, sperm associated 1 GAL3ST2 11q13 cation channel, sperm associated 1 SF3B2 11cen-q23 splicing factor 3b, subunit 2, 145kDa PACS1 11q13.1 phosphofurin acidic cluster sorting protein 1 KLC2 11q13.1 phosphofurin acidic cluster sorting protein 1 RAB1B 11q12 RAB1B, member RAS oncogene family MGC50896 11q13.1 hypothetical protein MGC50896 YIF1 11q13 Yip1 interacting factor homolog (S. cerevisiae) MGC33486 11q13.1 hypothetical protein MGC33486
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
20 - 3601 - 800 - 2001 11350945
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestiveintestinelarge intestinecolon highly
 liver   highly
Respiratorylung   highly
Skin/Tegumentskin    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Connectivebone   
Epithelialbarrier/lining   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one leucine zipper motif
  • four sumoylation sites
  • conjugated sumoylated
    HOMOLOGY
    interspecies homolog to murine Sart1
    ortholog to S. Cerevisiae Prp24
    Homologene
    FAMILY
    CATEGORY antigen
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • playing an essential role for the recruitment of the tri-snRNP to the pre-spliceosome in the spliceosome assembly pathway
  • involved in the regulation of proliferation
  • regulator of CFLAR and drug-induced activation of caspase-8
  • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction with UBL5 (an important role for UBL5 is the correct subcellular targeting of SART1, although our data suggest that UBL5 is likely to perform other roles in splicing as well)
  • target protein for SUMO1 and SUMO2
  • UBL5 binds non-covalently to a conserved element termed HIND, which is present in the spliceosomal protein SART1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to atopy
    Variant & Polymorphism SNP C774T/C1454G
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS