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FLASH GENE
Symbol SARS2 contributors: mct - updated : 18-03-2011
HGNC name seryl-tRNA synthetase 2, mitochondrial
HGNC id 17697
Corresponding disease
HUPRA hyperuricemia, pulmonary hypertension, renal failure in infancy, and alkalosis syndrome
Location 19q13.2      Physical location : 39.405.903 - 39.421.536
Synonym symbol(s) SYS, SARS, SERS, SARSM, SerRSmt, mtSerRS, FLJ20450
EC.number 6.1.1.11
DNA
TYPE functioning gene
STRUCTURE 15.63 kb     16 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
16 - 2077 58.2 518 - 2000 10764807
17 - 2083 - 520 - 2000 10764807
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus   moderately
Lymphoid/Immunespleen   highly
 tonsils   predominantly
Nervousbrain    
Reproductivefemale systemuteruscervix moderately
 female systemovary  moderately
Visualeye    
cell lineage
cell lines
fluid/secretion highly in blood
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a catalytic core
  • a N-terminal extension involved in tRNA binding
  • mono polymer homomer , dimer
    isoforms Precursor
    HOMOLOGY
    interspecies homolog to rattus Sars2 (86.6 pc)
    homolog to murine Sars2 (86.2 pc)
    Homologene
    FAMILY
  • class II aminoacyl-tRNA synthetase family
  • type-1 seryl-tRNA synthetase subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,matrix
    basic FUNCTION
  • catalyzing the attachment of serine to tRNA(Ser)
  • being able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
  • could participate in the biosynthesis of selenocysteinyl-tRNA in the mitochondria
  • CELLULAR PROCESS protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism other
    signaling
  • aminoacyl-tRNA biosynthesis
  • selenocysteinyl-tRNA(Sec) biosynthesis
  • a component
    INTERACTION
    DNA
    RNA
  • binding to tRNA
  • small molecule nucleotide,
  • ATP
  • protein
  • interacting with NFYA, NFYB, NFYC (NFYs influences directionality of transcription from the bidirectional MRPS12/SARS2 promoter)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) HUPRA
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS