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FLASH GENE
Symbol SARAF contributors: mct/npt - updated : 01-10-2014
HGNC name store-operated calcium entry-associated regulatory factor
HGNC id 28789
Location 8p12      Physical location : -
Synonym name
  • HBV X-transactivated gene 3 protein
  • protein FOAP-7
  • transmembrane protein 66
  • HBV XAg-transactivated protein 3
  • SOCE-associated regulatory factor
  • HBV X-transactivated gene 3 protein
  • Synonym symbol(s) FLJ22274, FOAP-7, HSPC035, MGC8721, XTP3, TMEM66
    DNA
    TYPE functioning gene
    STRUCTURE 20.20 kb     6 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 2171 36.9 339 - 2012 22464749
    5 - 1992 - 167 - 2012 22464749
  • SARAF-S
  • lacks the second exon of the full-length SARAF and results in a shorter open reading frame (ORF), corresponding to AA 173339
  • EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Endocrinepancreas   highly
    Lymphoid/Immunethymus   highly
    Nervousbrain   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a cleavable signal peptide (AA 130)
  • an ER-luminal facing domain (AA 31172)
  • a single putative transmembrane domain (AA 173195)
  • a cytoplasm facing domain (AA 196339)
  • a serine-proline rich domain followed by a cluster of basic residues at its C-terminal tail that may aid its interaction with the plasma membrane phospholipids
  • HOMOLOGY
    Homologene
    FAMILY
  • TMEM66 family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    text
  • is an endoplasmic reticulum membrane resident protein that associates with STIM to facilitate slow Ca2+-dependent inactivation of SOCE
  • SARAF ability to translocate into ER-PM regions depends primarily on the presence of STIM proteins
  • basic FUNCTION
  • is a negative regulator of store operated calcium entry (SOCE)
  • plays a key role in shaping cytosolic Ca2+ signals and determining the content of the major intracellular Ca2+ stores, a role that is likely to be important in protecting cells from Ca2+ overfilling
  • negatively regulates store operated calcium entry into cells and protects cells from calcium overfilling
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with STIM proteins
  • SARAF, with STIM2, may act on a similar Ca2+ permeation pathway
  • SARAF and STIM1 associate under resting conditions and that SOCE activation promotes molecular rearrangements between STIM1 and SARAF C termini in an ORAI1-dependent manner
  • STIM1 CTID domain determines access of SARAF to SOAR to regulate ORAI1 channel function
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS