SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,organelle,endoplasmic reticulum
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| intracellular,cytoplasm,organelle,Golgi
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| intracellular,cytoplasm,cytosolic
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text
| peripheral membrane protein associated with the endoplasmic reticulum and golgi stacks, in particular in the juxta-nuclear golgi region |
basic FUNCTION
| involved in the intracellular trafficking of proteins in COP-coated vesicles |
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involved in the vesicular COPII dependent transport of proteins from the endoplasmic reticulum (ER) to the Golgi apparatus (Silvain 2008) |
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playing an important role in processes involving erythroid cell proliferation and differentiation |
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plays a significant role in the assembly, organization, and function of the coat protein complex II, a critical complex for the transport of proteins from the endoplasmic reticulum to the Golgi |
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SAR1A and SAR1B proteins lower membrane rigidity at low concentrations, and at high concentrations, increase membrane rigidity |
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SAR1A, SAR1B GTPase coordinates the assembly of coat protein complex-II (COPII) at specific sites of the endoplasmic reticulum (ER) |
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SAR1A antagonizes the lipoprotein secretion-promoting activity of SAR1B, both isoforms modulate the expression of genes encoding cholesterol biosynthetic enzymes and the synthesis of cholesterol |
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SAR1B promotes the secretion of hepatic lipids but also adds regulation of cholesterol synthesis to SAR1B's repertoire of transport functions |
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importance of SAR1B in organs involved in lipid transport and/or calcium trafficking such as the liver, intestine, skeletal muscle and heart |
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SAR1A, SAR1B dimerization is responsible for the formation of constrictive membrane curvature |
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SAR1B GTPase is a key component of Coat protein complex II (COPII)-coated vesicles that bud from the endoplasmic reticulum to export newly synthesized proteins |
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SAR1B overexpression contributes to regulation of Cholestérol (CHOL) transport and metabolism by facilitating rapid uptake and transport of CHOL |
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Sar1B GTPase is one of the critical proteins governing chylomicron secretion by the small intestine |