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FLASH GENE
Symbol SAP18 contributors: mct - updated : 26-01-2013
HGNC name sin3-associated polypeptide, 18kDa
HGNC id 10530
Location 13q12.11      Physical location : 21.714.652 - 21.723.223
Synonym name
  • cell growth inhibiting protein 38
  • histone deacetlyase complex subunit SAP18
  • Synonym symbol(s) SAP18P, SP18, MGC27131, GIG38, 2HOR0202
    DNA
    TYPE functioning gene
    STRUCTURE 8.57 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 2318 - 172 - 1997 9150135
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivepharynx   highly
    Endocrineparathyroid   highly
    Hearing/Equilibriumearinnercochlea highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to murine Sap18
    Homologene
    FAMILY histone deacetylase complex family
    CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • cooperates with SUFU to repress transcription by recruiting the SAP18-SIN3 complex to promoters containing the Gli-binding element
  • play a key role in gene-specific recruitment of the HDAC complex by a number of transcription factors including GLI, GAGA, and Bicoid
  • functional role of SAP18 as a protein-protein adapter module
  • promotes Krüppel-dependent transcriptional repression by enhancer-specific histone deacetylation
  • both RNPS1 and, surprisingly, SAP18 strongly modulated splicing regulation
  • potentially involved in multiple cellular processes, from gene regulation to mRNA processing
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component with SIN3 and HDAC1
  • RNPS1, ACIN1, and SAP18 form the apoptosis- and splicing-associated protein (ASAP) complex, which is also part of the exon junction complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • directly interacts with SIN3 and enhances SIN3-mediated transcriptional repression when tethered to the promoter
  • interacting with SUFU, and galectin 3
  • HIV-1 integrase and SMARCB1 bind SAP18 and selectively recruit components of SIN3a-HDAC1 complex into HIV-1 virions
  • assembles a nuclear speckle-localized splicing regulatory multiprotein complex including RNPS1 and ACIN1 via its ubiquitin-like fold
  • PNN physically interacts with RNPS1 and SAP18, forming an alternative ternary complex, PSAP
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS