| basic FUNCTION
| may act as a negative regulator of the cell-intrinsic antiviral response  |
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may act as a negative regulator of the immunostimulatory DNA response and may have a protective role in preventing self-activation of innate immunity |
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interferon-induced protein in human macrophages and dendritic cells |
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HIV-1 restriction factor that blocks early-stage virus replication in dendritic and other myeloid cells, and is the target of the lentiviral protein Vpx, which can relieve HIV-1 restriction |
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important roles in immunoregulation and cerebral vascular hemeostasis |
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antiretroviral protein expressed in cells of the myeloid lineage that inhibits an early step of the viral life cycle |
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may be the restriction factor that renders dendritic cells refractory to HIV-1 infection |
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through the putative nucleotidase activity, may degrade or prevent accumulation of HIV DNA |
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implicated in inhibition of HIV-1 infection in macrophages |
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potent deoxynucleoside GTP-stimulated triphosphohydrolase that converts deoxynucleoside triphosphates to the constituent deoxynucleoside and inorganic triphosphate |
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restricts HIV-1 replication by hydrolysing the majority of cellular dNTPs, thus inhibiting reverse transcription and viral complementary DNA (cDNA) synthesis |
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HIV-1 restriction factor that is targeted by the HIV-2 accessory protein Vpx in myeloid lineage cells |
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SAMHD1, TREX1, and RNase H2 participate in a cellular nucleic acid metabolic pathway that overlaps the interferon-mediated innate antiviral and inflammatory responses |
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