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FLASH GENE
Symbol SAMD4A contributors: mct - updated : 10-09-2013
HGNC name sterile alpha motif domain containing 4A
HGNC id 23023
Location 14q22.2      Physical location : 55.034.636 - 55.260.033
Synonym name
  • sterile alpha motif domain containing 4
  • smaug homolog
  • Synonym symbol(s) KIAA1053, DKFZP434H0350, SAMD4, Smaug, SMG, SMGA, SMAUG1
    DNA
    TYPE functioning gene
    STRUCTURE 226.22 kb     12 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 6839 - 717 - 2005 16221671
    11 - 6575 - 630 - 2005 16221671
    - - 5576 - 345 - 2005 16221671
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • sterile alpha motif domain
  • HOMOLOGY
    interspecies homolog to murine 4933436G17Rik
    homolog to rattus LOC305826
    Homologene
    FAMILY
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • role for mammalian SAMD4A in RNA granule formation and translation regulation in neurons
  • translational repressor
  • forms mRNA-silencing foci located at postsynapses of hippocampal neurons
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • suppresses CUG-mediated muscle wasting at least in part via restoration of translational activity of CUGBP1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS