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FLASH GENE
Symbol SAFB2 contributors: mct/npt - updated : 08-07-2010
HGNC name scaffold attachment factor B2
HGNC id 21605
Location 19p13.3      Physical location : 5.587.010 - 5.622.938
Synonym symbol(s) KIAA0138
DNA
TYPE functioning gene
SPECIAL FEATURE head to head
text separated from SAFB by a short GC rich intergenic region that can be a bidirectional promoter containing a SP1 transcription factor binding site
STRUCTURE 35.93 kb     21 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Binding site   transcription factor
MAPPING cloned Y linked N status provisional
Physical map
PGSF1 19p13.3 pituitary gland specific factor 1a FEM1A 19p13.3 fem-1 homolog a (C.elegans) TRIF 19p13.3 fem-1 homolog a (C.elegans) TIP47 LOC342959 19p13.3 similar to Hypothetical protein CBG18249 UHRF1 19p13.3 ubiquitin-like, containing PHD and RING finger domains, 1 KIAA0876 PTPRS 19p13.3 protein tyrosine phosphatase, receptor type, S LOC388496 19 LOC388496 LOC148066 19p13.3 zinc and ring finger 4 PLAC2 19p13.3 placenta-specific 2 LOC148064 19p13.3 similar to small nuclear ribonucleoprotein E SAFB2 19p13.3 scaffold attachment factor B2 SAFB 19p13.3-p13.2 scaffold attachment factor B LOC125988 19p13.3 hypothetical gene LOC125988 SCDR10 19p13.3 short-chain dehydrogenase/reductase 10 RPL36 19p13.3-p13.2 ribosomal protein L36 PRSS15 19p13.2 protease, serine, 15 MGC39581 19p13.3 hypothetical protein MGC39581 MGC24975 19p13.3 hypothetical protein MGC24975 LOC56931 19p13.3 hypothetical protein from EUROIMAGE 1967720 FUT6 19p13.3 fucosyltransferase 6 (alpha (1,3) fucosyltransferase) NRTN 19p13.3 neurturin FUT3 19p13.3 fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group included) FUT5 19p13.3 fucosyltransferase 5 (alpha (1,3) fucosyltransferase) NDUFA11 19p13.3 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 11, 14.7kDa CAPS 19p13.3 calcyphosine RANBP3 19p13.3 RAN binding protein 3 RFX2 19p13.3 regulatory factor X, 2 (influences HLA class II expression) BGR 19p13.3 bubblegum related protein LOC388497 19 LOC388497 MLLT1 19p13.3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1 ASAH3 19p13.3 N-acylsphingosine amidohydrolase (alkaline ceramidase) 3
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
21 - 3334 - 953 - Olsen (2006)
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   lowly
 salivary gland   highly
Endocrinepancreas   lowly
Nervousnerve   highly
Visualeye   highly
cell lineage
cell lines breast cancer cell lines MCF-7BK, MDA-MB-31, T47D, ZR75, myeloblast cell line KG-1
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a RRM domain
  • a SAF box (SAP domain), interacting with SAFB
  • a nuclear localization signal
  • glu/arg and gly-rich regions
  • conjugated PhosphoP
    HOMOLOGY
    interspecies ortholog to murine ENSMUSG00000042625
    intraspecies paralog to SAFB
    Homologene
    FAMILY
  • scaffold attachement factor family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • can inhibit the proliferation via its estrogen receptor corepressor activity
  • like SAFB acts as a negative regulator of a TRA2B variable exon (Sergeant 2007)
  • may be involved in coordination of signaling and cytoskeletal responses
  • may be a novel breast tumor supressor gene
  • regulator of SRPK1 and SRPK2 activity underlining the importance of the assembly of transient intranuclear complexes in cellular regulation (Tsianou 2009)
  • involved in cell cycle regulation, apoptosis, differentiation, and stress response (Hammerich-Hille 2010)
  • SAFB and SAFB2 are nuclear matrix binding proteins that have been characterized as ESR1 corepressors
  • SAFB and SAFB2 are crucial repressors for ESR1 dynamics in association with the nuclear matrix and that their synergistic regulation of ESR1 mobility is sufficient for inhibiting ESR1 function
  • CELLULAR PROCESS cell life, proliferation/growth
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling hormonal
    a component
    INTERACTION
    DNA binding to the scaffold/matrix attachment region (S/MAR)
    RNA binding
    small molecule
    protein
  • interacting with SAFB, SCAM-1 and vinexin
  • can bind to estrogen receptor
  • ESR1 interacts with both SAFB1 and SAFB2 in the presence of E2
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS