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FLASH GENE

Symbol

SAFB2

contributors: mct/npt - updated : 30-11-2022

HGNC name	scaffold attachment factor B2
HGNC id	21605

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	19p13.3      Physical location : 5.587.010 - 5.622.938
Synonym symbol(s)	KIAA0138

DNA

TYPE	functioning gene
SPECIAL FEATURE	head to head
text	separated from SAFB by a short GC rich intergenic region that can be a bidirectional promoter containing a SP1 transcription factor binding site
STRUCTURE	35.93 kb     21 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence

Binding site   transcription factor

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_014649 21 - 3334 NP_055464 - 953 - 2020 32502422

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver       lowly   salivary gland       highly Endocrine pancreas       lowly Nervous brain       moderately Homo sapiens Visual eye       highly

cell lineage
cell lines	breast cancer cell lines MCF-7BK, MDA-MB-31, T47D, ZR75, myeloblast cell line KG-1
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a RRM domain
	a SAF box (SAP domain), interacting with SAFB
	a nuclear localization signal
	glu/arg and gly-rich regions

conjugated

PhosphoP

HOMOLOGY

interspecies

ortholog to murine ENSMUSG00000042625

intraspecies

paralog to SAFB

Homologene

FAMILY

scaffold attachement factor family

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	extracellular
	intracellular
	intracellular,cytoplasm
	intracellular,nucleus,nucleoplasm,nuclear bodies

basic FUNCTION	can inhibit the proliferation via its estrogen receptor corepressor activity
	like SAFB acts as a negative regulator of a TRA2B variable exon (Sergeant 2007)
	may be involved in coordination of signaling and cytoskeletal responses
	may be a novel breast tumor supressor gene
	regulator of SRPK1 and SRPK2 activity underlining the importance of the assembly of transient intranuclear complexes in cellular regulation (Tsianou 2009)
	involved in cell cycle regulation, apoptosis, differentiation, and stress response (Hammerich-Hille 2010)
	SAFB and SAFB2 are nuclear matrix binding proteins that have been characterized as ESR1 corepressors
	SAFB and SAFB2 are crucial repressors for ESR1 dynamics in association with the nuclear matrix and that their synergistic regulation of ESR1 mobility is sufficient for inhibiting ESR1 function
	potential role for SAFB2 in the differentiation and activity of Sertoli cells
	in addition to a role in basal cellular function in the brain, SAFB and SAFB2 proteins may serve as ESR1 corepressors in hormone-sensitive regions

CELLULAR PROCESS	cell life, proliferation/growth
	nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

hormonal

a component

INTERACTION

DNA	binding to the scaffold/matrix attachment region (S/MAR)

RNA

binding

small molecule

protein	interacting with SAFB, SCAM-1 and vinexin
	can bind to estrogen receptor
	ESR1 interacts with both SAFB1 and SAFB2 in the presence of E2
	ERH interacts directly in the nucleus with the C-terminal Arg-Gly-rich region of SAFB1/2 and co-localizes with it in the insoluble nuclear fraction
	SAFB and its paralogue, SAFB2, are nuclear matrix-binding proteins that negatively modulate ESR1-mediated transcription

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS