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FLASH GENE
Symbol SAE1 contributors: mct - updated : 16-10-2019
HGNC name SUMO1 activating enzyme subunit 1
HGNC id 30660
Location 19q13.32      Physical location : 47.634.079 - 47.713.892
Synonym name
  • sentrin/SUMO-activating protein AOS1
  • ubiquitin-like protein SUMO-1 activating enzyme
  • activator Of sumo 1
  • Synonym symbol(s) AOS1, SUA1, HSPC140, FLJ3091, UBLE1A
    DNA
    TYPE functioning gene
    STRUCTURE 79.81 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 2538 - 346 - 2001 11481243
    8 - 2377 - 266 - 2001 11481243
    7 - 2323 - 299 - 2001 11481243
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivefemale systemuteruscervix highly
    Skin/Tegumentskin   highly
    Urinarybladder   highly
    Visualeye   highlyHomo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer heteromer , dimer
    HOMOLOGY
    interspecies homolog to murine Uble1a
    Homologene
    FAMILY
  • ubiquitin-activating E1 family
  • CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    text
  • SAE1, UBE2I and PIAS1 are distributed in both nucleus and cytoplasm of ocular cell lines
  • basic FUNCTION
  • enzyme activator activity
  • protein heterodimerization activity
  • is indispensable for protein SUMOylation
  • promotes glioma cancer progression via enhancing AKT1 SUMOylation-mediated signaling pathway
  • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component UBA2 forms a tight heterodimer with SAE1 and it controls the trafficking of the heterodimer
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP
  • protein
  • ATP-dependent binding
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerbrainglioma/neuroblstoma
    targeting SUMOylation is a promising therapeutic strategy for human glioma
    ANIMAL & CELL MODELS