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FLASH GENE

Symbol

S1PR4

contributors: npt/mct - updated : 10/12/2008

HGNC name	sphingosine-1-phosphate receptor 4
HGNC id	3170

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	19p13.3      Physical location : 3.178.735 - 3.180.329
Synonym name	endothelial differentiation, G-protein-coupled receptor 6
	endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 6
	S1P receptor Edg-6
Synonym symbol(s)	EDG6, LPC1, S1P4, SLP4

DNA

TYPE	functioning gene
STRUCTURE	1.56 kb     1 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed S1PR4 1 - 1582 41 384 - Holdsworth (2004)

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune tonsils         Nervous brain       highly Respiratory lung

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow       Lymphoid

cell lineage
cell lines	Burkitt lymphoma cell lines
fluid/secretion

at STAGE

physiological period

fetal, pregnancy

Text	fetal tissues

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	seven transmembrane domains 7TM
	glutamic acid in the third transmembrane domain of the S1P receptors is a general selectivity switch regulating response to S1P over the closely related phospholipids, LPA

HOMOLOGY

interspecies	homolog to murine Edg6
	ortholog to Drosophila Mbf1
	ortholog to C.elegans H21p03.1

Homologene

FAMILY	G protein coupled receptor superfamily
	lysophospholipid/lysosphingolipid receptor family

CATEGORY

receptor membrane G

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	activating phospholipase C
	endothelial differentiation, receptor putative lysophospho or lysosphingolipids
	regulating lymphocyte cell signaling
	increasing cytolosic calcium ion concentration

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

immunity/defense

PATHWAY

metabolism

signaling

signal transduction

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

lipid and lipid-derived ligands

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS