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FLASH GENE
Symbol S1PR4 contributors: npt/mct - updated : 10/12/2008
HGNC name sphingosine-1-phosphate receptor 4
HGNC id 3170
Location 19p13.3      Physical location : 3.178.735 - 3.180.329
Synonym name
  • endothelial differentiation, G-protein-coupled receptor 6
  • endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 6
  • S1P receptor Edg-6
  • Synonym symbol(s) EDG6, LPC1, S1P4, SLP4
    DNA
    TYPE functioning gene
    STRUCTURE 1.56 kb     1 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    1 - 1582 41 384 - Holdsworth (2004)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunetonsils    
    Nervousbrain   highly
    Respiratorylung    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    Lymphoid    
    cell lineage
    cell lines Burkitt lymphoma cell lines
    fluid/secretion
    at STAGE
    physiological period fetal, pregnancy
    Text fetal tissues
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • seven transmembrane domains 7TM
  • glutamic acid in the third transmembrane domain of the S1P receptors is a general selectivity switch regulating response to S1P over the closely related phospholipids, LPA
  • HOMOLOGY
    interspecies homolog to murine Edg6
    ortholog to Drosophila Mbf1
    ortholog to C.elegans H21p03.1
    Homologene
    FAMILY
  • G protein coupled receptor superfamily
  • lysophospholipid/lysosphingolipid receptor family
  • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • activating phospholipase C
  • endothelial differentiation, receptor putative lysophospho or lysosphingolipids
  • regulating lymphocyte cell signaling
  • increasing cytolosic calcium ion concentration
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
  • lipid and lipid-derived ligands
  • REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS