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FLASH GENE
Symbol S1PR3 contributors: npt/ - updated : 02-03-2006
HGNC name sphingosine-1-phosphate receptor 3
HGNC id 3167
Location 9q22.1      Physical location : 91.606.361 - 91.619.924
Synonym name
  • S1P receptor EDG3
  • G protein-coupled receptor, endothelial differentiation gene-3
  • endothelial differentiation, sphingolipid G-protein-coupled receptor, 3
    • Synonym symbol(s) GPCR, FLJ37523, LPB3, MGC71696, S1P3, EDG3, EDG-3, FLJ93220
    DNA
    TYPE functioning gene
    STRUCTURE 13.56 kb     2 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 4221 42 378 - -
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Endocrinepancreas    
    Nervousbrain   highly
    Reproductivemale systemprostate  highly
    Urinarykidney   highly
    Visualeye   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta (highly)
    PROTEIN
    PHYSICAL PROPERTIES Hydrophobic
    STRUCTURE
    motifs/domains
  • seven hydrophobic transmembrane domains (7 TM)
    • HOMOLOGY
    interspecies homolog to murine Edg3
    Homologene
    FAMILY
  • G protein coupled receptor superfamily
    • CATEGORY immunity/defense , receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • contributing to the regulation of angiogenesis and vascular endothelial cell function and regulation of blood lymphocyte number
  • having redundant or cooperative functions for the development of a stable and mature vascular system during embryonic development
  • modulating intracellular Ca2+ homeostasis
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with F2R/SPHK1 (signalling controls dissemination of inflammation from the lymphatics)
  • cooperation between TLR4 and S1PR1 or S1PR3 demonstrates that TLR4 and GPCR can interact to enhance cytokine production in epithelial cells
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS