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FLASH GENE

Symbol

S1PR3

contributors: mct - updated : 25-02-2016

HGNC name	sphingosine-1-phosphate receptor 3
HGNC id	3167

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	9q22.1      Physical location : 91.606.361 - 91.619.924
Synonym name	S1P receptor EDG3
	G protein-coupled receptor, endothelial differentiation gene-3
	endothelial differentiation, sphingolipid G-protein-coupled receptor, 3
Synonym symbol(s)	GPCR, FLJ37523, LPB3, MGC71696, S1P3, EDG3, EDG-3, FLJ93220

DNA

TYPE	functioning gene
STRUCTURE	13.75 kb     2 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_005226 2 - 4221 NP_005217 42 378 - 2004 15138255

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly Endocrine pancreas         Nervous brain       highly Reproductive male system prostate     highly Urinary kidney       highly Visual eye       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text	placenta (highly)

PROTEIN

PHYSICAL PROPERTIES		Hydrophobic
STRUCTURE

motifs/domains

seven hydrophobic transmembrane domains (7 TM)

HOMOLOGY

interspecies

homolog to murine Edg3

Homologene

FAMILY

G protein coupled receptor superfamily

CATEGORY

immunity/defense , receptor membrane G

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,cytosolic

basic FUNCTION	contributing to the regulation of angiogenesis and vascular endothelial cell function and regulation of blood lymphocyte number
	S1PR3 signaling directs immature B cells to a bone marrow microenvironment important for both tolerance induction and maturation
	mediates the chemotactic effect of S1P in macrophages and plays a causal role in atherosclerosis by promoting inflammatory monocyte/macrophage recruitment and altering smooth muscle cell behavior
	having redundant or cooperative functions for the development of a stable and mature vascular system during embryonic development
	essential roles of S1PR1 and S1PR3 in human hepatic stellate cells motility and activation
	critical signaling molecule mediating cell proliferation and vascular permeability
	modulating intracellular Ca2+ homeostasis
	signalling though S1PR3 suppresses cell cycle progression to regulate function in muscle satellite cells
	migration of macrophages, toward S1P is determined by the S1P receptor expression profile, with S1PR1/S1PR3 stimulating and S1PR2 attenuating migration
	S1PR2 and S1PR3, likely are collectively essential mediators of eyelid closure during development
	S1PR1 and S1PR3 are responsible for S1P-induced migration of human bone marrow-derived mesenchymal stem cells (BMSCs)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	interacting with F2R/SPHK1 (signalling controls dissemination of inflammation from the lymphatics)
	cooperation between TLR4 and S1PR1 or S1PR3 demonstrates that TLR4 and GPCR can interact to enhance cytokine production in epithelial cells
	important role for S1PR2 and S1PR3 in S1P/HGF-mediated EC barrier responses that are associated with their complex formation with ITGB4

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   in abdominal aortic aneurysms

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	elevated total S1PR3 plasma concentrations (> 251 pg/ml) were linked to sepsis and acute lung injury (ALI) mortality
Therapy target

ANIMAL & CELL MODELS