| basic FUNCTION
| participating in sphingosine 1-phosphate-induced cell proliferation, survival and transcriptional activation |
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activator of MAPK |
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playing a dominant role in the coupling of S1P to phospholipse D in myoblasts and that the down-regulation of the receptor subtype is responsible for the specific uncoupling of S1P signalling to PLD in myotubes |
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having redundant or cooperative functions for the development of a stable and mature vascular system during embryonic development |
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modulate intracellular Ca2+ homeostasis |
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role of S1PR2 as a potent regulator of the inflammatory response within vascular endothelium |
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play a critical role in regulating human mast cell functions, including degranulation and cytokine and chemokine release  |
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role for a migration inhibitory receptor, S1PR2, in promoting GC B-cell confinement to Germinal centers (GCs) |
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while S1PR1 mediates chemoattraction toward S1P in bone marrow, where S1P concentration is low, S1PR2 mediates chemorepulsion in blood, where the S1P concentration is high |
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S1PR1 and S1PR2 function potentially cooperatively to regulate vascular development |
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S1PR1, S1PR2 coordinately induce mesenchymal cell migration through S1P activation of complementary kinase pathways |
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S1PR1 and S1PR2 cooperatively regulate embryonic vascular patterning and endothelial barrier function by influencing the organization of F-actin and tight junction proteins |
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plays a key role in the permeability and inflammatory responses of the vascular endothelium during endotoxemia |
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critical in the immune, nervous, metabolic, cardiovascular, musculoskeletal, and renal systems |
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migration of macrophages, toward S1P is determined by the S1P receptor expression profile, with S1PR1/S1PR3 stimulating and S1PR2 attenuating migration |
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S1PR2 and S1PR3, likely are collectively essential mediators of eyelid closure during development |
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link between S1PR2 signaling and BBB (blod-brain-barriere) polarity, that implicate S1PR2 in sex-specific patterns of disease during CNS autoimmunity |
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in S1P-induced migration of human bone marrow-derived mesenchymal stem cells (BMSCs), S1PR2 mediates the inhibition of migration |
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S1PR1 and S1PR2 play crucial roles in hyperglycemia-induced endothelial cell dysfunction |
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inhibition of endothelial S1PR2 signaling diminishes endothelial senescence-associated functional impairments and atherogenic stimuli-induced endothelial activation |
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modulates endotoxin-induced inflammation in endothelium |
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is a critical receptor in macrophage, impairs phagocytosis and antimicrobial defense in the pathogenesis of sepsis |
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plays a critical role in the induction of cerebrovascular permeability, development of intracerebral haemorrhage and neurovascular injury in experimental stroke |
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in the surrounding normal cells plays a positive role in the apical elimination of the transformed cells, and a role in epithelial defense against cancer (EDAC) |
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can exert its influence on inner ear function through regulation of inner ear fluid homeostasis or through changes in expression of other essential inner ear proteins |
