| basic FUNCTION
| involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation (epidermal differentiation) |
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involved in the development of epithelial skin tumors |
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playing a role in the inflammatory response to lipopolysaccharide by inducing the release of neutrophils from the bone marrow and directing their migration to the inflammatory site |
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playing a pivotal role during sepsis |
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S100A8/S100A9 levels are likely to be maintained in conditions where IL10 is raised, and these proteins may contribute to viral persistence in patients infected by some RNA viruses  |
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bacterial flagellin induces the upregulation of S100A8/S100A9 via a TLR5-dependent mechanism in epidermal keratinocytes (PMID/ |
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cytokine-induced potentiated S100A8 and S100A9 expression under conditions, is able to aggravate proinflammatory conditions via activation of the AGER pathway |
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is a potent chemoattractant and also an anti-oxidant, and both roles may be important in the developing placenta |
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pivotal roles of S100A8 and S100A9 in the propagation of inflammation and keratinocyte proliferation in psoriasis |
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S100A8 and S100A9 themselves function as pro-angiogenic and chemotactic factors, generating a psoriatic milieu in skin |
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S100A8 and/or S100A9 promote endothelial cell proliferation, survival, and angiogenesis both directly and by inducing keratinocytes to produce pro-angiogenic cytokines |
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S100A8 and S100A9 are Ca(2+)-binding proteins that are associated with acute and chronic inflammation and cancer |
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S100A8/A9 (calprotectin) negatively regulates G2/M cell cycle progression and growth of squamous cell carcinoma |
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role for S100A8 and S100A9 in redox-sensitive biological responses, including pro-inflammatory cytokine secretion |
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S100A8/A9 (calprotectin) and S100A12 proinflammatory mediators are found at inflammatory sites and in the serum of patients with inflammatory or autoimmune diseases |
