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FLASH GENE

Symbol

S100A2

contributors: mct/npt - updated : 10-02-2016

HGNC name	S100 calcium binding protein A2
HGNC id	10492

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	1q21      Physical location : 153.533.586 - 153.538.306
Synonym name	protein S-100L
Synonym symbol(s)	CAN19, S100L, MGC111539

DNA

TYPE	functioning gene
SPECIAL FEATURE	component of a cluster
STRUCTURE	4.72 kb     3 Exon(s)

Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 3 - 970 - 97 - Koch (2007)

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive pharynx       highly Respiratory respiratory tract larynx     highly Urinary bladder       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial barrier/lining

cells

System Cell Pubmed Species Stage Rna symbol Skin/Tegument keratinocyte

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	two calcium binding domains with an EF-hand motif
	one S100 specific N-terminus
	one classical C-terminus

mono polymer

homomer , dimer

HOMOLOGY

Homologene

FAMILY

S-100 family

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION	EF-hand calcium-binding S100 protein functioning as tumor suppressor
	calmodulin-like protein, TP53-inducible, readily oxidized in keratinocytes subjected to oxidative stress
	playing a crucial role in the differentiation of keratinocytes

CELLULAR PROCESS	cell life, differentiation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

constituent of epidermal diffentiation complex

INTERACTION

DNA

RNA

small molecule	metal binding,
	Ca2+
	binding Zn2+ with a high affinity

protein	direct transcriptional target of TP53 homologues during keratinocyte differentiation
	with S100A1, S100A4 and S100A6, interacting with MDM2, making the binding to MDM2 a general feature of S100 proteins
	S100A1, S100A2, S100A6, and S100B proteins specifically interact with PPP5C-tetratricopeptide repeat (TPR) domain

cell & other

REGULATION

induced by	p53
		p63 splice variant TAp63gamma

Other

regulated by both Zn2+ and Ca2+, and suggest that Zn2+ might deactivate S100A2 by inhibiting response to intracellular Ca2+ signals

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   in lymph node metastases of head and neck cancer tumoral     --over   in Barrett's adenocarcinomas

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS