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FLASH GENE
Symbol S100A14 contributors: mct - updated : 06-04-2018
HGNC name S100 calcium binding protein A14
HGNC id 18901
Location 1q21.3      Physical location : 153.586.733 - 153.588.790
Synonym name
  • breast cancer membrane protein 84
  • S100-type calcium binding protein A15
  • koebnerisin
  • Synonym symbol(s) LOC57402, S100A15, BCMP84
    DNA
    TYPE anonymous DNA segment
    SPECIAL FEATURE component of a cluster
    STRUCTURE 2.66 kb     4 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map cen - S100A9 - S100A12 - S100A8 - S100A7 - S100A6 - S100A5 - S100A4 - S100A3 - S100A2 - S100A13 - S100A1 - S100A14 - qter
    Authors Pietas (02)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 1075 - 104 - 2015 25502330
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   lowly
    Digestiveintestinelarge intestinerectum highly
     intestinelarge intestinecolon highly
    Endocrinethyroid   highly
    Reproductivefemale systemovary  lowly
     female systemuterus  moderately
     male systemprostate  lowly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two EF-hand calcium binding domain at the N terminus, with high homology to the S100A7
  • N glycosylation site
  • a myristoylation motif
  • several potential protein kinase phosphorylation sites
  • two helix-loop-helix (HLH) structural motifs, characteristic of calcium binding sites
  • HOMOLOGY
    intraspecies homolog to S100A13
    Homologene
    FAMILY S100 protein family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm,nuclear bodies
    basic FUNCTION
  • having calcium ion binding activity
  • involved in epidermal differentiation and inflammation and might therefore be important for the pathogenesis of psoriasis and other diseases
  • might function as a cancer suppressor working in the TP53 pathway and play a role in esophageal carcinogenesis
  • S100A7 and koebnerisin (S100A14) are released by keratinocytes during physiological wound healing
  • Psoriasin and koebnerisin show antifibrotic effects and may lead to novel preventive and therapeutic strategies for fibroproliferative diseases
  • EF-hand calcium-binding protein that has been reported to exert its biological effects on different types of cells
  • has a crucial role in cervical cancer progression
  • is a calcium-binding protein involved in cell proliferation and differentiation as well as the metastasis of human tumors
  • may have a role in the induction of differentiation and inhibition of cell metastasis in gastric cancer
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • S100A14 promotes cell motility and invasiveness by regulating the expression and function of MMP2 in a TP53-dependent manner
  • S100A14 interacts with S100A16 and regulates its expression in human cancer cells
  • connection between SHH-GLI1 signaling and S100A4 regulation, which imply that S100A4 might be one of the key factors in EMT mediated by SHH-GLI1 signaling in pancreatic cancer (pMID: 25072505)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in human serous ovarian carcinoma
    tumoral     --low  
    in esophageal squamous cell carcinoma (ESCC)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS