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FLASH GENE
Symbol S100A13 contributors: mct/npt - updated : 03-07-2009
HGNC name S100 calcium binding protein A13
HGNC id 10490
Location 1q21.3      Physical location : 153.591.279 - 153.606.568
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
STRUCTURE 15.30 kb     3 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Physical map
CDC2L2 1p36.33 cell division cycle 2-like 2 CDC2L1 1p36.33 cell division cycle 2-like 1 (PITSLRE proteins) LOC391201 1 similar to hypothetical protein FLJ10709 LOC391212 1 similar to Olfactory receptor 2T5 S100A3 1q21 S100 calcium binding protein A3 LOC391203 1 similar to 14.5 kDa translational inhibitor protein (p14.5) (UK114 antigen homolog) LOC388765 1 hypothetical gene supported by BK000152 LOC391209 1 similar to ribosomal protein L36; 60S ribosomal protein L36 PNRC2 1p36.11 proline-rich nuclear receptor coactivator 2 LOC391213 1 similar to seven transmembrane helix receptor LOC388766 1 hypothetical gene supported by BC059409; NM_022834 LOC388770 1 similar to TBP-associated factor 1A isoform 1; SL1, 48kD subunit FUSIP1 1p36.11 FUS interacting protein (serine-arginine rich) 1 LOC388571 1 similar to bA476I15.3 (novel protein similar to septin) LOC391214 1 similar to seven transmembrane helix receptor S100A16 1q21 S100 calcium binding protein A16 LOC388778 1 LOC388778 LOC391215 1 similar to Olfactory receptor 2T5 LOC388572 1 LOC388572 LOC387625 1 solute carrier family 35, member E2 S100A14 1q21.1 S100 calcium binding protein A14 LOC388767 1 hypothetical gene supported by AK024028; NM_031921 S100A13 1q21 S100 calcium binding protein A13 LOC388768 1 similar to hypothetical protein KIAA0454 - human (fragment) LOC127295 1p36.11 similar to 60S ribosomal protein L36 FLJ23476 1p34.2 ischemia/reperfusion inducible protein LOC391216 1 similar to seven transmembrane helix receptor
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 951 - 98 - Oh, Wicki (1996)
4 - 743 - 98 - Oh, Wicki (1996)
3 - 667 - 98 - Oh, Wicki (1996)
3 - 638 - 98 - Oh, Wicki (1996)
3 - 606 - 98 - Oh, Wicki (1996)
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestiveintestinesmall intestine   
Endocrinepancreas    
Reproductivefemale systemovary   
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two calcium binding domains with an Ef-hand-motif
  • two characteristic EF-hand domains
  • one S-100 specific Nter, one classical Cter
  • HOMOLOGY
    Homologene
    FAMILY
  • S-100 family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
    text under stress, FGF1 and S100A13 colocalize at the plasma membrane (Graziani 2009)
    basic FUNCTION
  • involved in the regulation of FGF1 and SYT1 release in response to temperature stress
  • plays an important role in the secretion of FGF1 and interleukin 1alpha, two pro-angiogenic factors released by the endoplasmic reticulum/Golgi-independent non-classical secretory pathway (Imai 2006)
  • copper binding protein able to enhance the export of FGF1 in response to stress and to induce the formation of a multiprotein aggregate responsible for FGF1 release (Landriscina 2006)
  • calcium binding protein, known to participate in the non-classical secretion of signal peptide-less proteins, such as the acidic fibroblast growth factor (Kathir 2007)
  • participates also in the stress-dependent nonclassical export of IL1A and specifically associates with FGF1 at stress in glial cells (Graziani 2009)
  • small calcium-binding protein critical for FGF1 export (Graziani 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
  • protein
  • interacting with IL1A
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    of S100A13 and VEGFA expression correlated with the activation of angiogenesis in high-grade astrocytic gliomas (Landriscina 2006)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS