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FLASH GENE
Symbol S100A11 contributors: mct - updated : 04-05-2011
HGNC name S100 calcium binding protein A11 (calgizzarin)
HGNC id 10488
Location 1q21.3      Physical location : 152.004.982 - 152.009.511
Synonym name calgizzarin
Synonym symbol(s) CAAF1, S100C, MLN70
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
STRUCTURE 4.53 kb     3 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 595 - 105 - 2000 10623577
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
digestiveesophagus    
Digestivemouthgingiva   
Lymphoid/Immunespleen    
Reproductivefemale systemovary  highly
 male systemprostate   
Respiratoryrespiratory tractlarynx  highly
Urinarybladder   highly
 kidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoietic    
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticleukocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal fragment has the same activity as the full-length protein (it is phosphorylated and binds to nucleolin) (
  • two calcium binding domains with an EF-hand motif
  • one S100 specific domain
  • one classical Cterminal domain
  • mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to bovine CAAF1
    Homologene
    FAMILY S-100 family
    CATEGORY motor/contractile
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text
  • initially expressed in the cytoplasm, it is transported to the nucleus by the action of nucleolin
  • basic FUNCTION
  • involved in the regulation of actin activated myosin-MGH ATPase activity
  • may be having a role in the regulation of membrane activities, probably in relation to Ca(2+) fluxes in skeletal muscle cells
  • may be functioning in motility, invasion, and tubulin polymerization
  • plays a dual role in growth regulation of keratinocytes and epithelial cells (
  • targets RAD54B to sites of DNA DSB repair sites and have a novel function in CDKN1A-based regulation of cell cycle (
  • suppresses the growth of keratinocytes through CDKN1A activation and induces cell differentiation (
  • EF-hand protein that undergo a calcium-induced conformational change allowing them to interact with other proteins and produce a biological response
  • dimeric EF-hand calcium-binding protein
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component constituent of epidermal diffentiation complex
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    calcium Ca2+ (Calcium binding to S100A11 results in a large conformational change that uncovers a broad hydrophobic surface used to interact with phospholipid-binding proteins and facilitate membrane vesiculation events)
    protein
  • binding to the TP53 tetramerization domain (
  • specific interaction between S100A11 and RAD54B
  • N-terminal tail of ANXA1 can interact with either membranes or S100A11 protein, and it adopts the conformation of an amphipathic alpha-helix upon these interactions
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    marker of malignant transformation of various tissues, decreasing significantly after the transformation
    constitutional     --low  
    in atopic dermatitis (
    tumoral     --over  
    in colorectal cancer compared with adjacent normal tissues
    tumoral     --over  
    in the early stage of pancreatic carcinogenesis and decreased during subsequent progression to cancer (
    Susceptibility to lipodystrophy and diabetes
    Variant & Polymorphism
    Candidate gene
    Marker
  • novel diagnostic marker in breast carcinoma (analysis of S100A11 expression in breast cancer may be an effective tool help in detection of early-stage breast cancer) (
  • Therapy target
    ANIMAL & CELL MODELS