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FLASH GENE
Symbol RYBP contributors: mct - updated : 14-01-2015
HGNC name RING1 and YY1 binding protein
HGNC id 10480
Location 3p13      Physical location : 72.423.743 - 72.495.774
Synonym name
  • YY1- and E4TF1/hGABP-associated factor-1
  • apoptin-associating protein 1
  • death effector domain-associated factor
  • ring1 interactor RYBP
  • Synonym symbol(s) YEAF1, AAP1, DEDAF
    DNA
    TYPE functioning gene
    STRUCTURE 72.03 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 4678 24.69 228 - 2006 17070805
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen   highly
    Cardiovascularheart   highly
    Reproductivefemale systemuterus   
     male systemprostate  highly
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Lymphoid    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a zinc-finger domain
  • secondary structure
  • noncompact protein with little residual secondary structure, lacking a well-defined tertiary structure
  • HOMOLOGY
    interspecies ortholog to murine Rybp
    Homologene
    FAMILY
    CATEGORY transcription factor , tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • involved in regulation of transcription
  • induced apoptosis in various tumor cell lines, but not in primary fibroblasts or mesenchymal cells
  • involved in the regulation of both cytoplasmic and nuclear events of apoptosis
  • inducing cell-cycle arrest and is involved in the TP53 response to DNA damage, interacting with MDM2 and decreasing MDM2-mediated TP53 ubiquitination, leading to stabilization of TP53 and an increase in TP53 activity (Chen 2009)
  • RYBP and IFT57 may functionally interact in the apoptotic processes that accompany normal murine neural development
  • zinc finger protein with an essential role during embryonic development, which binds transcriptional factors, Polycomb products, and mediators of apoptosis
  • CELLULAR PROCESS cell life, cell death/apoptosis
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    text transcriptional repressor
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • binding to the Polycomb transcriptional repressor complex and to the transcription factor YY1
  • interacting specifically with the E2F2 and E2F3 family members (Schlisio 2002)
  • interacting with apoptin (Danen-van Oorschot 2004)
  • interacting with DED-containing proteins and encoding pro-apoptotic functions
  • RYBP can synergize with IFT57 to enhance CASP8-mediated apoptosis and also appears to be essential for IFT57-mediated apoptosis
  • interacting with MDM2 (Chen 2009)
  • RYBP stimulates the activity of RNF2 toward H2AK119ub1, suggesting a central role in Polycomb repressive complex 1 function
  • RYBP-Polycomb repressive complex 1 is recruited to target loci in embryonic stem cells and is also involved in XIST RNA-mediated silencing, the latter suggesting a wider role in Polycomb silencing
  • CBX7 is necessary for recruitment of RNF2 to chromatin, whereas RYBP enhances the Polycomb repressive complex 1 enzymatic activity
  • RYBP inhibits the polyubiquitination-mediated proteasomal degradation of RNF2 independently of its ubiquitin (Ub)-protein isopeptide ligase (E3) ligase activity
  • RYBP modulates stability and function of RNF2 through targeting UBE3A
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS