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FLASH GENE
Symbol RXRG contributors: mct - updated : 04-05-2020
HGNC name retinoid X receptor, gamma
HGNC id 10479
Location 1q23.3      Physical location : 165.370.158 - 165.414.592
Synonym name
  • nuclear receptor subfamily 2 group B member 3
  • Synonym symbol(s) NR2B3, RXRC
    DNA
    TYPE functioning gene
    STRUCTURE 44.43 kb     10 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 2263 - 340 - 2018 29892012
    10 - 1966 - 463 - 2018 29892012
    9 - 1670 - 340 - 2018 29892012
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Nervousbrain   moderately
    Reproductivefemale systembreastmammary gland highly
    Respiratorylung    
    Visualeye   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal modulator domain
  • a central bipartite (class II) zinc finger DNA binding domain
  • a nuclear receptor dna-binding domain
  • a C terminal steroid-binding domain
  • mono polymer heteromer , dimer
    HOMOLOGY
    interspecies ortholog to murine Rxrg
    homolog to Xenopus Xl.878
    homolog to C.elegans H01A20.1
    Homologene
    FAMILY
  • steroid/thyroid/retinoic receptor superfamily
  • nuclear hormone receptor family
  • NR2 subfamily
  • CATEGORY transcription factor , receptor nuclear
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • involved in retinoic acid response pathway
  • is a positive regulator of endogenous oligodendrocyte precursor cell differentiation and remyelination
  • RXRG may likely play an important role in tight control of glucose metabolism in the fasting-feeding cycle
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
    zinc Zn2+
    protein
  • binding to retinoic acid X receptor
  • RXRG as well as RXRA increased SREBF1 promoter activity in hepatocytes
  • RXRG positively regulates the PPAR signaling pathway
  • cell & other
    REGULATION
    activated by 9-cis-retinoic acid,only (9-cis-RA)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral germinal mutation      
    in familial isolated pituitary adenoma
    tumoral     --low  
    appears to provide mechanistic benefits to transformed cells towards the acquisition of resistance to apoptosis hallmark of cancer
    Susceptibility
  • to type 2 Diabetes with retinopathy
  • to familial combined hyperlipidemia (FCHL)
  • Variant & Polymorphism other
  • SNP of RXRG Rs3753898 may be related to the genetic susceptibility of type 2 Diabetes
  • RXRG rs3818569 SNP is associated with diabetic retinopathy development
  • RXRG Ser14 was more frequent in FCHL than in other primary hyperlipidemia and in controls
  • Candidate gene
    Marker
  • is an independent predictor of longer breast cancer-specific survival and distant metastasis-free survival
  • in ER-positive tumours, high expression of RXRG was associated with better patient outcome regardless of adjuvant systemic therapy
  • Therapy target
    SystemTypeDisorderPubmed
    neurologyacquired 
    might be a pharmacological target for regenerative therapy in the CNS
    ANIMAL & CELL MODELS
  • ablation of RXRG in mice leads to depressive-like behaviors including increased despair and anhedonia, which were accompanied by reduced expression of dopamine D2 receptor in the shell of nucleus accumbens (NAc) and altered serotonin signaling
  • transgenic mice overexpressing Rxrg specifically in skeletal muscle showed increased gene expression of Srebf1 with increased triglyceride content in their skeletal muscles