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FLASH GENE
Symbol RXFP3 contributors: npt/mct - updated : 26-07-2006
HGNC name relaxin/insulin-like family peptide receptor 3
HGNC id 24883
Location 5p13.2      Physical location : 33.936.490 - 33.939.023
Synonym name
  • somatostatin and angiotensin-like peptide receptor
  • G-protein coupled receptor SALPR
  • relaxin 3 receptor 1
  • relaxin family peptide receptor 3
  • Synonym symbol(s) SALPR, GPCR135, RLN3R1, RXFPR3, MGC1419982, MGC142000
    DNA
    TYPE functioning gene
    STRUCTURE 1.85 kb     1 Exon(s)    1 Copie(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    1 - 2533 - 469 - -
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivesalivary gland   lowly
    Endocrineadrenal gland   highly
     pancreas   lowly
     placenta   lowly
    Nervousbraindiencephalonamygdala predominantly
     brainbasal nucleicorpus callosum predominantly
     brainmidbrainsubstantia nigra predominantly
     brainlimbic systemhippocampus predominantly
     brainbasal nucleicaudate nucleus predominantly
     spinal cord   predominantly
    Reproductivefemale systembreastmammary gland lowly
     male systemtestis  lowly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminus and extracellular loop 2 domains of RXFP3 and RXFP4 are involved in ligand binding while TM2, 3, and 5 are critical for receptor activation
  • seven transmembrane domains
  • two putative N-glycosylation sites
  • C-terminal SER or THR residues may be phosphorylated
  • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to murine Rln3r1
    Homologene
    FAMILY
  • G protein coupled receptor 1 family
  • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • binding of the ligand relaxin 3 inhibits cAMP accumulation
  • receptor for angiotensin II, mediating its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling hormonal , signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to relaxin 3
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS