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FLASH GENE
Symbol RUSC1 contributors: mct - updated : 09-06-2017
HGNC name RUN and SH3 domain containing 1
HGNC id 17153
Location 1q21.3      Physical location : 155.290.639 - 155.300.909
Synonym name
  • nesca protein
  • new molecule containing SH3 at the carboxy-terminus
  • Synonym symbol(s) NESCA
    DNA
    TYPE functioning gene
    STRUCTURE 10.27 kb     9 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned   linked   status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 3503 - 902 - 2012 22404429
    10 - 3185 - 796 - 2012 22404429
    8 - 2705 - 427 - 2012 22404429
    9 - 2568 - 433 - 2012 22404429
    9 - 2250 - 327 - 2012 22404429
    9 - 2469 - 400 - 2012 22404429
    9 - 2525 - 496 - 2012 22404429
    8 - 2367 - 433 - 2012 22404429
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinepancreas    
    Nervousbrain     Homo sapiensFetal
    Respiratorylung    
    Visualeye     Homo sapiensFetal
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    IMPRINTING paternally
    text expressed maternally (from maternally inherited transcripts)
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a RUN domain at its N-terminus, that can bind H-Ras, a downstream signaling molecule of NTRK1, with high affinity
  • a leucine zipper motif,
  • no catalytic domain
  • one VWFC domain
  • a C-terminal SH3 domain
  • mono polymer homomer , trimer
    HOMOLOGY
    Homologene
    FAMILY Rusc family of proteins
    CATEGORY adaptor
    SUBCELLULAR LOCALIZATION     plasma membrane,junction
        intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytosolic,vesicle
    intracellular,cytoplasm,cytoskeleton,microtubule
    intracellular,nucleus
    basic FUNCTION
  • putative adapter protein
  • functions as an adapter involved in neuronal vesicular transport including vesicles containing soluble N-ethylmaleimide sensitive factor attachment protein receptors that are essential to exocytosis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
  • RUSC1 participates in the NGF-NTRK1 signaling pathway
  • RUSC1 and RUSC2 are novel components of the vertebrate HH pathway
  • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • novel IKBKG-interacting protein, RUSC1, an adapter molecule previously shown to be involved in the NGF-pathway via the NTRK1
  • RUSC1 and RUSC2 interact with SUFU and restrict the response of cells to HH signaling
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS