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FLASH GENE
Symbol RUSC1 contributors: mct - updated : 09-06-2017
HGNC name RUN and SH3 domain containing 1
HGNC id 17153
Location 1q21.3      Physical location : 155.290.639 - 155.300.909
Synonym name
  • nesca protein
  • new molecule containing SH3 at the carboxy-terminus
  • Synonym symbol(s) NESCA
    DNA
    TYPE functioning gene
    STRUCTURE 10.27 kb     9 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned   linked   status provisional
    Physical map
    ZFP67 1q21.2 zinc finger protein 67 homolog (mouse) FLJ32934 1q22 hypothetical protein FLJ32934 FLJ32785 1q22 hypothetical protein FLJ32785 ADAM15 1q21.3 a disintegrin and metalloproteinase domain 15 (metargidin) EFNA4 1q21-q22 ephrin-A4 EFNA3 1q21-q22 ephrin-A3 EFNA1 1q21-q22 ephrin-A1 LOC55974 1q22 stromal cell protein DPM3 1q21.2 dolichyl-phosphate mannosyltransferase polypeptide 3 KCP2 TRIM46 1q21-22 tripartite motif-containing 46 MUC1 1q21 mucin 1, transmembrane THBS3 1q21-q23 thrombospondin 3 MTX1 1q21 metaxin 1 LOC388704 1 similar to GBA protein MTX1P 1q21 metaxin 1 pseudogene GBA 1q21 glucosidase, beta; acid (includes glucosylceramidase) C1orf2 1q21 chromosome 1 open reading frame 2 SCAMP3 1q21 secretory carrier membrane protein 3 CLK2 1q21 CDC-like kinase 2 HCN3 1q22 hyperpolarization activated cyclic nucleotide-gated potassium channel 3 PKLR 1q21 pyruvate kinase, liver and RBC FDPS 1q21.2 farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase) FLJ35976 1q22 hypothetical protein FLJ35976 RUSC1 1q21-q22 RUN and SH3 domain containing 1 ASH1L 1q21 ash1 (absent, small, or homeotic)-like (Drosophila) LOC284620 1q22 similar to CLDN6 MRPS29P1 1q21.3 mitochondrial ribosomal protein S29 pseudogene 1 FLJ10504 1q22 misato
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 3503 - 902 - 2012 22404429
    10 - 3185 - 796 - 2012 22404429
    8 - 2705 - 427 - 2012 22404429
    9 - 2568 - 433 - 2012 22404429
    9 - 2250 - 327 - 2012 22404429
    9 - 2469 - 400 - 2012 22404429
    9 - 2525 - 496 - 2012 22404429
    8 - 2367 - 433 - 2012 22404429
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinepancreas    
    Nervousbrain     Homo sapiensFetal
    Respiratorylung    
    Visualeye     Homo sapiensFetal
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    IMPRINTING paternally
    text expressed maternally (from maternally inherited transcripts)
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a RUN domain at its N-terminus, that can bind H-Ras, a downstream signaling molecule of NTRK1, with high affinity
  • a leucine zipper motif,
  • no catalytic domain
  • one VWFC domain
  • a C-terminal SH3 domain
  • mono polymer homomer , trimer
    HOMOLOGY
    Homologene
    FAMILY Rusc family of proteins
    CATEGORY adaptor
    SUBCELLULAR LOCALIZATION     plasma membrane,junction
        intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytosolic,vesicle
    intracellular,cytoplasm,cytoskeleton,microtubule
    intracellular,nucleus
    basic FUNCTION
  • putative adapter protein
  • functions as an adapter involved in neuronal vesicular transport including vesicles containing soluble N-ethylmaleimide sensitive factor attachment protein receptors that are essential to exocytosis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
  • RUSC1 participates in the NGF-NTRK1 signaling pathway
  • RUSC1 and RUSC2 are novel components of the vertebrate HH pathway
  • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • novel IKBKG-interacting protein, RUSC1, an adapter molecule previously shown to be involved in the NGF-pathway via the NTRK1
  • RUSC1 and RUSC2 interact with SUFU and restrict the response of cells to HH signaling
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS