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FLASH GENE
Symbol RUFY2 contributors: npt - updated : 18-11-2009
HGNC name RUN and FYVE domain containing 2
HGNC id 19761
Location 10q21.3      Physical location : 70.103.276 - 70.167.051
Synonym name
  • Rab4-interacting protein related
  • antigen MU-RMS-40.17
  • Synonym symbol(s) KIAA1537, RABIP4R, FLJ10063, ZFYVE13
    DNA
    TYPE functioning gene
    STRUCTURE 63.67 kb     18 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC340888 10q22.1 similar to aldo-keto reductase family 1, member B10; aldose reductase-like 1; aldo-keto reductase family 1, member B11 (aldose reductase-like); aldose reductase-like peptide; aldose reductase-related protein; small intestine reducta JDP1 10q21.1 similar to aldo-keto reductase family 1, member B10; aldose reductase-like 1; aldo-keto reductase family 1, member B11 (aldose reductase-like); aldose reductase-like peptide; aldose reductase-related protein; small intestine reducta LOC389974 10 similar to 60S ribosomal protein L12 SIRT1 10q21.3 sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae) DKFZP564G092 10q22.1 DKFZP564G092 protein MYOP ATOH7 10q22.2 atonal homolog 7 (Drosophila) LOC389975 10 similar to keratin 19; keratin, type I cytoskeletal 19; keratin, type I, 40-kd; cytokeratin 19; 40-kDa keratin intermediate filament precursor gene MAWBP 10q21.1 similar to keratin 19; keratin, type I cytoskeletal 19; keratin, type I, 40-kd; cytokeratin 19; 40-kDa keratin intermediate filament precursor gene HNRPH3 10q22 heterogeneous nuclear ribonucleoprotein H3 (2H9) RUFY2 10q22.2 RUN and FYVE domain containing 2 DNA2L 10q21.3-q22.1 DNA2 DNA replication helicase 2-like (yeast) SLC25A16 10q21.3-q22.1 solute carrier family 25 (mitochondrial carrier; Graves disease autoantigen), member 16 LCX 10q21 leukemia-associated protein with a CXXC domain CARP-1 10q22.1 cell-cycle and apoptosis regulatory protein 1 C10orf24 10q22.1 chromosome 10 open reading frame 24 DDX50 10q22.1 DEAD (Asp-Glu-Ala-Asp) box polypeptide 50 DDX21 10q21 DEAD (Asp-Glu-Ala-Asp) box polypeptide 21 KIAA1279 10q22.1 KIAA1279 LOC389976 10 similar to actin 3 - fruit fly (Drosophila melanogaster) (fragments) PRG1 10q22.1 proteoglycan 1, secretory granule VPS26 10q21.1 vacuolar protein sorting 26 (yeast) SUPV3L1 10q22.1 suppressor of var1, 3-like 1 (S. cerevisiae) FLJ22761 10q22.1 hypothetical protein FLJ22761
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 2696 - 403 - -
    - - 4520 - 641 - -
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal RUN domain
  • a C terminal FYVE domain
  • two coiled-coid domain in-between
  • HOMOLOGY
    interspecies homolog to Drosophila CG4043
    homolog to murine Rabip4
    Homologene
    FAMILY
    CATEGORY transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endosome
    text colocalizing with early endosome antigen marker (EEA1),RAB4
    basic FUNCTION unknown
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    text endosomal traffick
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS