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FLASH GENE
Symbol RUFY1 contributors: mct/npt/pgu - updated : 13-03-2010
HGNC name RUN and FYVE domain containing 1
HGNC id 19760
Location 5q35.3      Physical location : 178.977.570 - 179.037.019
Synonym name
  • FYVE-finger protein EIP1
  • Rab4-interacting protein
  • zinc finger FYVE domain-containing protein 12
  • Synonym symbol(s) ZFYVE12, FLJ22251, RABIP4
    DNA
    TYPE functioning gene
    STRUCTURE 59.45 kb     17 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    CLK4 5q35 CDC-like kinase 4 ZNF354A 5q35.3 zinc finger protein 354A LOC391856 5 similar to acetoacetyl-CoA synthetase; acetoacetate-CoA ligase; homolog of C. elegans supressor of ras 5 (sur-5) LOC391857 5 similar to hypothetical protein MGC2574 ZNF354B 5q35-3 zinc finger protein 354B LOC340042 5q35.3 similar to hypothetical protein MGC48972 PIGFP1 5q35 phosphatidylinositol glycan, class F, pseudogene 1 FLJ21628 5q35.3 hypothetical protein FLJ21628 ZNF454 5q35.3 zinc finger protein 454 GRM6 5q35 glutamate receptor, metabotropic 6 LOC391858 5 similar to F-box and WD-40 domain protein 2 LOC345462 5q35.3 similar to hypothetical protein 9630041N07 ZNF354C 5q35.3 zinc finger protein 354C LOC345463 5q35.3 similar to UNR protein ADAMTS2 5q23 a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 2 LOC391859 5 similar to Tb-291 membrane associated protein LOC389351 5 similar to 6-pyruvoyl-tetrahydropterin synthase RUFY1 5q35.3 RUN and FYVE domain containing 1 HNRPH1 5q353 heterogeneous nuclear ribonucleoprotein H1 (H) LOC202404 5q35.3 hypothetical LOC202404 LOC285679 5q35.3 hypothetical protein LOC285679 LOC389352 5 similar to High mobility group protein 4 (HMG-4) (High mobility group protein 2a) (HMG-2a) CANX 5q35 calnexin MAML1 5q35 mastermind-like 1 (Drosophila) FLJ12121 5q35.3 hypothetical protein FLJ12121 LTC4S 5q35 leukotriene C4 synthase MGAT4B 5q35 mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isoenzyme B SQSTM1 5q35 sequestosome 1 LOC51149 5q35.3 truncated calcium binding protein KIAA0676 5q35.1-q35.3 truncated calcium binding protein RNF130 5q35.3 ring finger protein 130 LOC255426 LOC391860 5 similar to 40S ribosomal protein S8 MAPK9 5q35 mitogen-activated protein kinase 9 GFPT2 5q34-q35 glutamine-fructose-6-phosphate transaminase 2
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    17 - 2628 69 600 - 2004 14617813
    18 - 2439 69 600 - 2004 14617813
    18 - 2644 80 708 - 2004 14617813
  • RABIP4 prime
  • N-terminal extension of 108 AAs
  • peripheral membrane protein, which colocalized with internalized transferrin and EEA1 on early endosomes
  • may coordinate the activities of RAB4A and RAB5A, regulating membrane dynamics in the early endosomal system
  • EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal RUN domain
  • a C terminal FYVE-finger domain
  • two coiled-coid domain in-between
  • HOMOLOGY
    interspecies ortholog to murine Rabpip4
    Homologene
    FAMILY
  • RUFY family
  • CATEGORY transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    text present in early endosomes, because it is colocated with endogenous Early Endosome Antigen 1
    basic FUNCTION
  • effector of RAB4A, controling early endosomal traffic possibly by activating a backward transport step from recycling to sorting endosomes
  • controls SLC2A4 trafficking and plays a role in its endocytotic trafficking
  • via its interaction with RAB4A, regulate integrin trafficking and are involved in the migration of NIH 3T3 fibroblasts
  • novel function for AP3B1 and RUFY1 in regulating lysosome positioning through an interorganellar pathway
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    text endosomal traffick
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ETK
  • RAB14 binds in a GTP-dependent manner to RUFY1, which had been originally identified as a RAB4A effector
  • cell & other
    REGULATION
    Other phosphorylated by ETK
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS