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FLASH GENE
Symbol RTP1 contributors: mct - updated : 26-09-2017
HGNC name receptor transporter protein 1
HGNC id 28580
Location 3q27.3      Physical location : 186.915.273 - 186.919.251
Synonym name
  • 3CxxC-type zinc finger protein 1
  • receptor (chemosensory) transporter protein 1
  • Synonym symbol(s) Z3CXXC1
    DNA
    TYPE functioning gene
    STRUCTURE 3.98 kb     2 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 2265 - 263 - 2017 28586385
    - - - - - - 2012 22570474
  • Receptor-transporting protein 1 short
  • is an accessory protein to mammalian Odorant receptor (OR) and facilitates their trafficking to the cell-surface membrane and ligand-induced responses in heterologous cells
  • C terminus of RTP1S may be interacting with ORs
  • EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Olfactory (smell)olfactory bulb     Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Olfactoryolfactory receptor Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY RTP family member
    CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • RTP1 and RTP2 in particular play significant roles in the translocation of ORs to the plasma membrane as well as in the functioning of ORs
  • RTP1, RTP2 are associated with OR proteins, and facilitate the OR trafficking to the plasma membrane when coexpressed in mammalian cell lines
  • RTP1, RTP2 play a dual role in both normal OR trafficking and determining olfactory receptor (OR) gene choice probabilities
  • RTP1 and RTP2 could play different roles in the OR trafficking process
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS