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FLASH GENE

Symbol

RTN4RL2

contributors: mct - updated : 15-03-2014

HGNC name	reticulon 4 receptor-like 2
HGNC id	23053

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	11q12.1      Physical location : 57.228.338 - 57.244.383
Synonym name	Nogo-66 receptor homolog 1
Synonym symbol(s)	NgR2, NGRH1

DNA

TYPE	functioning gene
STRUCTURE	17.01 kb     3 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_178570 3 - 2220 NP_848665 - 420 - -

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine large intestine colon     Nervous brain         Reproductive female system ovary       Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective bone

cells

System Cell Pubmed Species Stage Rna symbol Lymphoid/Immune dendritic cell Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

N-terminal fragment (NTF-NgRH1) containing a leucine-rich repeat region

HOMOLOGY

Homologene

FAMILY

reticulon family

CATEGORY

receptor

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION

RTN4RL2 and RTN4R might be involved in the regulation of immune cell migration in the CNS

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	MAG is a ligand for RTN4R and RTN4RL2
	is bound by substrate recognition side of FBXO2, via the sugar binding domain of FBXO2, and finally could also regulate its level

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --low   of RTN4RL2, and RTN4R promotes the adhesion of dendritic cells, interaction that could be important in neuroinflammatory disorders such as multiple sclerosis

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS