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FLASH GENE
Symbol RTN3 contributors: mct/npt - updated : 01-12-2014
HGNC name reticulon 3
HGNC id 10469
Location 11q12.3      Physical location : 63.448.921 - 63.527.357
Synonym name
  • neuroendocrine-specific protein-like 2
  • ASY interacting protein
  • NSP-like protein II
  • isoforme III
  • ASY interacting protein
  • homolog of ASY protein
  • Synonym symbol(s) ASYIP, HAP, NSPL2, NSPLII, RTN3-A1
    DNA
    TYPE functioning gene
    STRUCTURE 78.44 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    text structure a first large intron
    MAPPING cloned Y linked   status provisional
    Map cen - POLR2G - VMD2 - FTH1 - [D11S432 - COX8A - D11S4627 ] - PYGM PYGM - qter
    Authors Moreira (99)
    Text [RTN3 ]
    Physical map
    MGC34821 11q12.3 hypothetical protein MGC34821 LOC387601  putative UST1-like organic anion transporter CCND2P 11q13 cyclin D2 pseudogene LOC387775 11 similar to organic anion transporter 6 SLC22A9 11q13.1 solute carrier family 22 (organic anion/cation transporter), member 9 HRLP5 11q13.2 H-rev107-like protein 5 LGALS12 11q13 lectin, galactoside-binding, soluble, 12 (galectin 12) TMSL5 11 thymosin-like 5 RARRES3 11q23 retinoic acid receptor responder (tazarotene induced) 3 HRASLS2 11q13.1 HRAS-like suppressor 2 HRASLS3 11q13.1 HRAS-like suppressor 3 LOC283241 11q13.1 hypothetical protein LOC283241 DKFZP564J0863 11q13.1 DKFZP564J0863 protein RTN3 11q13 reticulon 3 LOC144097 11q13.1 hypothetical protein BC007540 MARK2 11q12-q13 MAP/microtubule affinity-regulating kinase 2 LOC283248 11q13.1 hypothetical protein LOC283248 FLJ13848 11q13.1 hypothetical protein FLJ13848 COX8 11q13.1 cytochrome c oxidase subunit VIII OTUB1 11q13.1 OTU domain, ubiquitin aldehyde binding 1 LRP16 11q11 LRP16 protein LOC387776 11 LOC387776 FLRT1 11q12-q13 fibronectin leucine rich transmembrane protein 1 STIP1 11q13.2 stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing protein) URP2 11q13.1 UNC-112 related protein 2 short form
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 2588 - 236 - 2007 10331947
    8 - 4919 - 1013 - 2007 10331947
    8 - 2645 - 255 - 2007 10331947
    - - 2332 - 214 - 2007 10331947
    - - 2529 - 241 - 2007 10331947
    9 - 4976 - 1032 - 2007 10331947
    8 - 4640 - 920 - 2007 10331947
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
    Nervousbrainforebraincerebral cortex   Homo sapiens
     brain   predominantly Homo sapiens
    Visualeyeretina   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervouscentral   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    endocrineendocrine cell
    Nervousneuron Homo sapiens
    Nervouspyramidal cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal luminal, negatively charged, reticulon domain
  • a first transmembrane stretch or domain (TM1) important for the membrane insertion
  • two hydrophobic transmembrane segments
  • a conserved C terminal region (TM2)
  • a QID triplet conserved among mammalian RTN members required for the binding of RTN to BACE1
  • a RHD domain with two hydrophobic stretches separated by a 66-amino acid loop
  • a short C-terminal tail
  • HOMOLOGY
    interspecies ortholog to murine Rtn3
    Homologene
    FAMILY
  • neuroendocrine-specific, NSP (reticulon) family
  • reticulon family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    text
  • anchored to membranes of the endoplasmic reticulum through its carboxy-terminal regions
  • localized in both endoplasmic reticulum and Golgi compartments in neurones
  • CRELD1 could partly change the localization of RTN3 from the endoplasmic reticulum to the plasma membrane and modulate the apoptotic activity of RTN3 through binding with it
  • basic FUNCTION
  • involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells
  • play an important role in modulating BACE1 activity and neuritic function
  • mark a distinct and abundant population of dystrophic neurites named RTN3 immunoreactive dystrophic neurites (RIDNs) in brains of Alzheimer disease (AD)
  • apoptosis-inducing protein
  • may play a role in the trafficking of the SALM (Synaptic adhesion-like molecules) family of adhesion molecules
  • negatively regulates autophagy to block the clearance of cytoplasmic PRNP aggregates
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with BACE1 (BACE1 mainly binds to the RTN monomer and disruption of the QID triplet does not interfere with the dimerization)
  • interacts with the beta-secretase, beta-site amyloid precursor protein-cleaving enzyme 1 (BACE1), and inhibits its activity to produce beta-amyloid protein
  • CRELD1 bound with RTN3 so as to increase the localization of RTN3 on the plasma membrane and decreased the apoptotic activity of RTN3 moderately
  • RTN3 has previously been shown to interact with BACE1 and negatively regulate BACE1 activity
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    neurologyneurodegenerativealzheimer
    blocking the formation of RTN3 immunoreactive dystrophic neurites may be a promising strategy to impede cognitive decline in the elderly and in AD patients
    ANIMAL & CELL MODELS