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FLASH GENE
Symbol RTKN2 contributors: mct - updated : 24-01-2009
HGNC name rhotekin 2
HGNC id 19364
Location 10q21.2      Physical location : 63.952.955 - 64.028.466
Synonym name
  • pleckstrin homology domain containing, family K member 1
  • Synonym symbol(s) DKFZp686J10120, PLEKHK1
    DNA
    TYPE functioning gene
    STRUCTURE 75.50 kb     12 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map cen - D10S2323 - D10S1640 - RTKN2 - D10S1652 - D10S1162 qter
    Physical map
    MRPS35P3 10q21 mitochondrial ribosomal protein S35 pseudogene 3 IPMK MDS029 UBE2D1 10q11.2-q21 ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast) TFAM 10q21 transcription factor A, mitochondrial BICC1 10q21.3 bicaudal C homolog 1 (Drosophila) LOC389971 10 hypothetical gene supported by U78798; NM_004620 KIAA1796 10q11 KIAA1796 protein FAM13C1 10q21 family with sequence similarity 13, member C1 MRPL50P4 10q23.1 family with sequence similarity 13, member C1 C10orf36 D10S170 ANK3 10q21 ankyrin 3, node of Ranvier (ankyrin G) LOC387684 10 similar to ADP-ribosylation factor-like protein 4 CDC2 10q21.1 cell division cycle 2, G1 to S and G2 to M RHOBTB1 10q22.1 Rho-related BTB domain containing 1 MGC35010 10q21.3 hypothetical protein MGC35010 MGC44593 10q21.3 hypothetical protein MGC44593 MRF2 10q21.3 hypothetical protein MGC44593 RTKN2 10q21.3 rhotekin 2 ZNF365 10q21.2 zinc finger protein 365 LOC387685 10 LOC387685 ATQL4 10q21 antiquitin-like 4 C10orf22 10q21.3 chromosome 10 open reading frame 22 EGR2 10q21.1 early growth response 2 (Krox-20 homolog, Drosophila) NRBF-2 TRIP8 10q22.1 thyroid hormone receptor interactor 8 LOC389972 10 similar to Px19-like protein MGC14425 10q22.1 hypothetical protein MGC14425 LOC221035 10q22.1 similar to DNA segment, Chr 10, University of California at Los Angeles 1 MRPL35P2 10q21.3 similar to DNA segment, Chr 10, University of California at Los Angeles 1 RPL7AP1 10q21.2 similar to DNA segment, Chr 10, University of California at Los Angeles 1 LOC143173 10q22.1 similar to activator of S phase kinase ANXA2P3 10q21-q22 annexin A2 pseudogene 3 VR22 10q22.2 alpha-catenin-like protein
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 6659 - 609 - Collier (2004)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineadrenal gland   highly
    Reproductivemale systemprostate   
     male systemtestis  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    cell cycle     cell cycle
    Text eye
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a class I Rho-binding domain
  • a pleckstrin homology (PH) domain
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION may play an important role in lymphopoiesis (Collier 2004)
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein target peptides (effectors) for the Rho-GTPases (Collier 2004)
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to uric acid nephrolithiasis (see UAN)
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS