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FLASH GENE
Symbol RTKN contributors: mct - updated : 18-12-2013
HGNC name rhotekin
HGNC id 10466
Location 2p13.1      Physical location : 74.652.988 - 74.669.060
Synonym symbol(s) B5
DNA
TYPE functioning gene
STRUCTURE 16.07 kb     12 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Map pter - HTRA2 - AUP1 - ACTG2 - SLC8A1 - RTKN - DCTN1 - cen
Authors Jang (97) Fu (00)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
12 - 2208 - 563 - 2000 10873388
13 - 2638 - 550 - 2000 10873388
12 - 2211 - 513 - 2000 10873388
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestine   highly
Nervousbrain     Homo sapiens
Reproductivemale systemprostate   
Skin/Tegumentskin   highly
Urinarybladder   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervouscentral    Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a Rho effector motif in its N-terminal ACTG2 region
  • tandem Rho binding domain class 1 and pleckstrin homology domain (PH)
  • a REM (Hr1) repeat
  • C-terminal SPV (Ser-Pro-Val) motif exhibited binding to the PDZ domain of GOPC, and Ser-435 in the C terminus of rhotekin is the potential site targeted by PRKD1, PRKD2, PRKD3
  • HOMOLOGY
    interspecies homolog to murine Rtkn
    Homologene
    FAMILY
    CATEGORY regulatory , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • binding GTP bound form of Rho inhibiting its GTPase activity
  • scaffold protein that interacts with GTP-bound Rho proteins
  • involved in bladder carcinogenesis and progression in bladder carcinoma
  • is a novel PKD substrate that regulates RhoA activity by enhancing its membrane association
  • is one of the key molecules in the differentiation of neural stem cells into neurons
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • with TIP1
  • interacting with GOPC (involvement of GOPC in the recruitment of Rhotekin to adherens junctions and playing a possible role in cell-polarity development and/or maintenance)
  • interact with a multidomain adaptor protein, vinexin, with a possible role at focal adhesion formation
  • its overexpression confers resistance to apoptosis by activating NFKB
  • role of rhotekin phosphorylation in the regulation of RHOA activity by modulating its anchoring in the plasma membrane
  • PRKG1 interacts with and phosphorylates rhotekin, thereby contributing to neurite outgrowth regulation
  • S100A4 interacts with the Rho-binding domain (RBD) of Rhotekin, thus connecting S100A4 to the Rho pathway, which permit S100A4 to complex with RHOA and switch Rho function from stress fiber formation to membrane ruffling to confer an invasive phenotype
  • cell & other
    REGULATION
    Phosphorylated by PRKD2, PRKD1, PRKD3 (phosphorylation of rhotekin by PRKD2 modulates the anchoring of the RHOA in the plasma membrane)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in bladder carcinoma in progression
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS