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FLASH GENE
Symbol RTF1 contributors: mct - updated : 17-04-2014
HGNC name Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
HGNC id 28996
Location 15q15.1      Physical location : 41.709.301 - 41.775.760
Synonym name
  • hypothetical protein KIAA0252
  • protein name RNA polymerase-associated protein RTF1 homolog
  • Synonym symbol(s) KIAA0252, GTL7
    DNA
    TYPE functioning gene
    STRUCTURE 66.46 kb     18 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    18 - 5038 - 710 - 2006 16882721
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a central region called the ORF-Association Region (OAR) was shown to be required for recruitment of PAF1C to chromatin, conserved domain also named the Plus3 domain after the presence of three invariant positively charged amino acids
  • a C-domain with unexpected similarity to the Ras family of small GTPases
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • RTF1 component of the PAF1 complex functions in NOTCH signaling
  • LEO1, but not RTF1, is necessary for the complex to bind RNA
  • RTF1, CDC73, and LEO1 have all been shown to play a role in recruitment of PAF1C to chromatin at active genes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • loss of either RTF1 or CDC73 results in the detachment of the PAF1 complex from Pol II and the chromatin form of actively transcribed genes
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS