| basic FUNCTION
| is an important regulator of cell survival  |
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implicated as an antirecombinase in that it disrupts D-loop formation during homologous recombination and is essential for the disassembly of T-loops during DNA replication |
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is required to prevent excess meiotic |
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negatively regulates recombination by disassembling D loop–recombination intermediates during DNA repair |
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implements the second level of crossover control by promoting noncrossovers |
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essential iron-sulfur cluster-containing helicase, that promotes synthesis-dependent strand annealing to direct DNA double-strand breaks into non-crossover outcomes during mitotic repair and in meiosis |
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role in telomere maintenance and homologous recombination |
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maintain telomere integrity in part by catalyzing T-loop disassembly during S phase |
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performs two distinct functions at telomeres: it disassembles T loops and also counteracts telomeric G4-DNA structures, which together ensure the dynamics and stability of the telomere |
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key protein for DNA replication, recombination, and repair and efficient elongation of telomeres by telomerase |
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helicase essential for telomere maintenance and regulation of homologous recombination |
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required to ensure genome integrity |
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implicated in telomere protection and elongation |
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functional RTEL1 contributes to T-circle formation, consistently with the apparently reduced T-circle formation in cells carrying RTEL1 mutations |
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essential DNA helicase that disassembles telomere loops (T loops) and suppresses telomere fragility to maintain the integrity of chromosome ends |
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plays a critical role in both telomere and genome-wide replication, which is crucial for genetic stability and tumor avoidance |
