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FLASH GENE
Symbol RSU1 contributors: - updated : 11-09-2006
HGNC name Ras suppressor protein 1
HGNC id 10464
Location 10p13      Physical location : 16.632.618 - 16.859.453
Synonym name suppressor of transformation by activated RAS
Synonym symbol(s) FLJ31034, RSP1
DNA
TYPE functioning gene
STRUCTURE 224.00 kb     9 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
Physical map
LOC283071 10p14 similar to hypothetical protein 9330140G23 HSP70-4 10p14 likely ortholog of mouse heat shock protein, 70 kDa 4 SUV39H2 10p13 suppressor of variegation 3-9 homolog 2 (Drosophila) DCLRE1C 10p14-p13 DNA cross-link repair 1C (PSO2 homolog, S. cerevisiae) LOC389940 10 similar to seven transmembrane helix receptor FLJ11106 10p13 hypothetical protein FLJ11106 LOC387634 10 similar to Acyl-CoA-binding protein (ACBP) (Diazepam binding inhibitor) (DBI) (Endozepine) (EP) MGC35468 10p13 hypothetical protein MGC35468 RPP38 10p13 ribonuclease P (38kD) NMT2 10p12.33-p12.32 N-myristoyltransferase 2 LOC221061 10p13 hypothetical protein LOC221061 ITGA8 10p13 integrin, alpha 8 FLJ13397 10p13 hypothetical protein FLJ13397 PTER 10p12 phosphotriesterase related LOC389941 10 similar to Gliacolin RSU1 10p13 Ras suppressor protein 1 CUBN 10p12.1 cubilin (intrinsic factor-cobalamin receptor) DNMT2 10p15.1 DNA (cytosine-5-)-methyltransferase 2 VIM 10p13 vimentin ST8SIA-VI 10p13 alpha 2,8-sialyltransferase PTPLA 10p14-p13 protein tyrosine phosphatase-like (proline instead of catalytic arginine), member a STAM 10p14-p13 signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 LOC340843 10p13 similar to protein of unknown function LOC340893 10p13 similar to protein of unknown function MRC1 10p13 mannose receptor, C type 1 SLC39A12 10p13 solute carrier family 39 (zinc transporter), member 12 CACNB2 10p12 calcium channel, voltage-dependent, beta 2 subunit
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 3769 31 277 - Dougherty
  • isoform 1
  • - - 3657 25.4 224 - Dougherty
  • lacking an alternate in-frame segment in the 5'UTR and 5' coding region
  • using a downstream start codon
  • isoform 2
  • EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivefemale systemplacenta  highly
    Respiratoryrespiratory tracttrachea  highly
    Urinarybladder   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    seven LRR (leucine-rich) repeats
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory , tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • suppressor of transformation by activated RAS
  • involved in the Ras signal transduction pathway, growth inhibition, and nerve-growth factor induced differentiation processes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    signal transduction pathway
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS