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FLASH GENE
Symbol RSAD2 contributors: mct - updated : 18-12-2019
HGNC name radical S-adenosyl methionine domain containing 2
HGNC id 30908
Location 2p25.2      Physical location : 7.017.795 - 7.038.363
Synonym name
  • viperin
  • virus inhibitory protein, endoplasmic reticulum -associated, interferon -inducible
  • Synonym symbol(s) cig5, vig1, 2510004L01Rik, cig33
    DNA
    TYPE functioning gene
    SPECIAL FEATURE arranged in tandem
    STRUCTURE 32.51 kb     6 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 3407 - 361 - 2019 30684519
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cells
    SystemCellPubmedSpeciesStageRna symbol
    not specificchondrocyte Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N-terminal leucine zipper motif, N-terminal transmembrane helix, amphipathic alpha-helix that is responsible for ER localization (
  • a domain associated with iron-sulfur cluster coordination
  • a middle region carrying a a CX(3)CX(2)C motif, which is conserved in the radical S-adenosyl-methionine (SAM) enzyme family
  • a highly conserved C-terminus
  • HOMOLOGY
    interspecies ortholog to rat Best5 or Vig1
    Homologene
    FAMILY radical S-adenosylmethionine (SAM) enzyme family
    CATEGORY immunity/defense
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,mitochondria,outer
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic,vesicle
    basic FUNCTION
  • radical SAM enzyme activity may play a key role in the broad antiviral actions of viperin
  • is the major effector underlying the ability of human cytomegalovirus (HCMV) to regulate cellular lipid metabolism
  • impaired respiratory syncytial virus (RSV) transmission by inhibiting virus filament formation, providing a basis for its anti-virus activity in RSV-infected cells
  • is an interferon-stimulated antiviral protein
  • possesses antiviral properties against a broad range of enveloped viruses
  • is antivirally active against many different viruses from different families and has been shown to inhibit several flaviviruses
  • interferon-inducible and evolutionary conserved protein that participates in the cell's innate immune response against a number of viruses
  • antiviral protein viperin controls chondrogenic differentiation by influencing secretion of soluble proteins
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with two molecules of the mevalonate pathway, geranyl pyrophosphate, and farnesyl pyrophosphate, involved in cholesterol biosynthesis, that might lead to defects in cholesterol synthesis
  • cell & other
    REGULATION
    induced by by IFNA, IFNB, IFNG, human cytomegalovirus (HCMV) infection, and the HCMV envelope protein, glycoprotein B
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS