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FLASH GENE
Symbol RRP1B contributors: mct/npt/shn - updated : 12-06-2011
HGNC name ribosomal RNA processing 1 homolog B (S. cerevisiae)
HGNC id 23818
Location 21q22.3      Physical location : 45.079.431 - 45.115.958
Synonym name
  • protein of unknown function, hypothetical homolog of S cerevisiae YDR087c
  • protein D4478 homolog
  • novel nuclear protein 1-like
  • RRP1-like protein B
  • ribosomal RNA processing protein 1 homolog B
  • Synonym symbol(s) KIAA0179, Nnp1, RRP1, NNP1L
    DNA
    TYPE functioning gene
    STRUCTURE 36.00 kb     16 Exon(s)
    MAPPING cloned Y linked N status provisional
    Map cen - D21S1890 - D21S1885 - RRP1B - D21S1259 - D21S1912 - qter
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    16 - 5087 84 758 - -
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   lowly Homo sapiens
    Digestiveintestinelarge intestinecolon lowly Homo sapiens
     intestinesmall intestine  lowly Homo sapiens
     liver   lowly Homo sapiens
    Endocrinepancreas   lowly Homo sapiens
    Lymphoid/Immunespleen   lowly Homo sapiens
     thymus   lowly Homo sapiens
    Nervousbrain   lowly Homo sapiens
    Reproductivefemale systemovary  lowly Homo sapiens
     female systemplacenta  lowly Homo sapiens
     male systemtestis  lowly Homo sapiens
    Respiratorylung   lowly Homo sapiens
    Urinarykidney   lowly Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal lowly Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticleukocyte Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • NH2-terminal RNA-binding Nop52 domain
  • three nuclear localization signals
  • HOMOLOGY
    interspecies homolog to yeast S.cerevisiae YDR087c,hypothetical
    ortholog to Rrp1b, Rattus norvegicus
    ortholog to Rrp1b, Mus musculus
    ortholog to RRP1B, Pan troglodytes
    intraspecies homolog to protein D4478
    Homologene
    FAMILY
  • RRP1 family
  • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,nucleolus
    text
  • with its interactors appear to co-localize at the perinuclear or perinucleolar regions, within the nucleoplasm, or at a combination of any of the three (Crawford 2009)
  • basic FUNCTION
  • form a central node which likely is a consequence of its physical interaction with the metastasis efficiency modifier SPA1
  • tumor progression and metastasis susceptibility candidate gene, that is potentially a dynamic modulator of transcription and chromatin structure (Crawford 2009)
  • interact with both heterochromatin and euchromatin-associated factors, suggesting that RRP1B probably plays a dynamic role in the regulation of gene expression (Crawford 2009)
  • required for the expression of certain E2F1 proapoptotic target genes and the induction of apoptosis by DNA-damaging agents (Paik 2010)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • physically interacts with many nucleosome binding factors, including histone H1X, poly(ADP-ribose) polymerase 1, TRIM28 and CSDA (cold shock domain protein A) (
  • E2F1-specific transcriptional target (both a novel E2F1 target and a novel coactivator and may prime cells for E2F1-dependent apoptosis)(
  • protein phosphatase 1, PP1 (
  • cell & other
  • association of RRP1B with condensed mitotic chromatin (
  • REGULATION
    induced by several DNA-damaging agents (Paik 2010)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --other  
    dysregulation in tumor progression and metastasis (Crawford 2009)
    Susceptibility
  • for breast cancer progression and metastasis susceptibility (
  • Variant & Polymorphism other constitutional polymorphism significantly associated with tumor progression in breast cancer
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS