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FLASH GENE
Symbol RRM1 contributors: SGE/npt - updated : 15-03-2010
HGNC name ribonucleotide reductase M1
HGNC id 10451
Location 11p15.4      Physical location : 4.115.923 - 4.160.105
Synonym name
  • ribonucleoside-diphosphate reductase M1 chain
  • ribonucleoside-diphosphate reductase large subunit
  • ribonucleotide reductase, R1 subunit
  • ribonucleotide reductase M1 polypeptide
    • Synonym symbol(s) R1, R1R, RIR1
    EC.number 1.17.4.1
    DNA
    TYPE functioning gene
    SPECIAL FEATURE opposite orientation
    text oriented in a head-to-tail configuration with the stromal interaction molecule 1 gene (STIM1), with the 3' end of STIM1 situated 1.6 kb from the 5' end of this gene
    STRUCTURE 44.18 kb     19 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    19 - 3234 90 792 - Pavloff 1992
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivestomach   highly
    Reproductivefemale systemuteruscervix highly
    Respiratoryrespiratory tractlarynx  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an ATP-cone domain
    • HOMOLOGY
    interspecies homolog to murine Rrm1 (97.6pc)
    homolog to rattus Rrm1-ps1 (87.4pc)
    Homologene
    FAMILY
  • ribonucleoside diphosphate reductase large chain family
    • CATEGORY enzyme , tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • putative metastasis suppressor (see TSG11D)
  • providing the precursors necessary for DNA synthesis
  • catalyzing the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
  • involved in tumor invasiveness and metastasis
  • involved in DNA repair during G1 phase (Niida 2010)
  • controls substrate specificity and global on/off enzyme activity
    • CELLULAR PROCESS nucleotide, replication
    nucleotide, repair
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism purine/pyrimidine
    signaling
    deoxyribonucleotides biosynthetic pathway
    a component
  • heterodimer of a large (M1) and a small chain (M2)
    • INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP binding
    • protein
  • interacts with RRM2B or RRM2
  • binding to KAT5 (Niida 2010)
    • cell & other
    REGULATION
    Other stimulated by ATP and inhibitied by dATP binding to the activity site
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in non-small cell lung cancer with good prognosis
    tumoral     --over  
    associated to overexpression of ERCC1, in lung tumor with excellent outcome
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
  • decreased by tranilast and may be a future novel chemotherapeutic strategy by Gemcitabine against pancreatic cancer (Mitsuno 2010)
  • diagnostic marker of survival in pancreatic cancer patients. only patients with low RRM1 derive benefits from gemcitabine (Akita 2009)
    • ANIMAL & CELL MODELS