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FLASH GENE
Symbol RRBP1 contributors: mct - updated : 27-05-2014
HGNC name ribosome binding protein 1
HGNC id 10448
Location 20p12.1      Physical location : 17.594.322 - 17.662.928
Synonym name
  • ES/130-related protein
  • ribosome receptor protein
  • 180 kDa ribosome receptor homolog
  • Synonym symbol(s) ES130, ES/130, FLJ36146, hES, RRp, p180
    DNA
    TYPE functioning gene
    STRUCTURE 68.61 kb     25 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    26 - 3792 - 977 - 2008 18083570
    25 - 3715 - 977 - 2008 18083570
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveesophagus   highly
     intestinelarge intestinecolon highly
    Endocrinepancreas   highly
     parathyroid   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a novel microtubule-binding domain (designated MTB1)with a predicted coiled-coil region and repeat domain, and strongly promoted bundle formation
  • a lysine-rich region that can directly interact with RNA
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic,ribosome
    intracellular,cytoplasm,cytoskeleton,microtubule
    text
  • a ribosome-binding protein located on the rough ER
  • microtubule-bundling protein on the ER
  • mainly observed to be in the cytoplasm with intense staining in the perinuclear region
  • basic FUNCTION
  • involved in early cardiac morphogenesis
  • acting as a ribosome receptor and mediating interaction between the ribosome and the endoplasmic reticulum membrane
  • microtubule-binding and -modulating protein
  • mediates interactions between the endoplasmic reticulum and microtubules mainly through the novel microtubule-binding and -bundling domain MTB1
  • central role in the terminal differentiation of secretory cells and tissues
  • novel function of RRBP1-abundant ER on the trans-Golgi network (TGN) expansion, both of which are highly developed in various professional secretory cells (PMId: 19932094)
  • is required for the efficient ER-anchoring of bulk poly(A) and of certain transcripts, such as placental alkaline phosphatase and calreticulin, to the ER
  • could alleviate ER stress and help cancer cell survive (PMId: 23318453)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • RRBP1 may involve in the regulation of mRNA stability of UPR components including ATF6 and HSPA5 (PMId: 23318453)
  • cell & other i5 ribosome binding
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in lung cancer patients
    tumoral     --over  
    in breast carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerlung 
    useful target in lung cancer treatment and a candidate for the development of new targeted therapeutics
    ANIMAL & CELL MODELS