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FLASH GENE
Symbol RRAGD contributors: mct - updated : 11-10-2014
HGNC name Ras-related GTP binding D
HGNC id 19903
Location 6q15      Physical location : 90.074.336 - 90.121.995
Synonym name Rag D protein
Synonym symbol(s) DKFZP761H171, bA11D8.2.1, RAGD, GTR2p
DNA
TYPE functioning gene
STRUCTURE 47.66 kb     7 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
7 - 4926 - 400 - 2004 14660641
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines Burkitt lymphoma
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • three GTP-binding motifs (PM1, PM2, PM3)
  • a potential leucine-zipper
  • a coiled-coil structure
  • mono polymer monomer
    HOMOLOGY
    interspecies homolog to murine Rragd
    homolog to rattus LOC297960
    homolog to yeast S.cerevisiae Gtr2p
    intraspecies homolog to RRAGC
    Homologene
    FAMILY RAG A subfamily of the Ras-like small G protein superfamily
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,lysosome
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    text changes its localization, depending on the nucleotide-bound state of RRAGA
    basic FUNCTION
  • GTPase activity
  • may be involved in nuclear protein import
  • do not directly stimulate the kinase activity of MTOR, but, like amino acids, promote the intracellular localization of MTOR to a compartment that also contains its activator RHEB
  • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • RRAGA forms a heterodimer with other G proteins, RRAGC and RRAGD, in a nucleotide-independent manner
  • INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    GTP binding
    protein
  • interacts with RRAGA
  • NOL8 is associated with RRAGC and RRAGD
  • bind raptor and mediate amino acid signaling to MTOR
  • a complex encoded by the LAMTOR1, LAMTOR2, LAMTOR3 genes, which we term Ragulator, interacts with the RRAGA, RRAGB, RRAGC, RRAGD, recruits them to lysosomes, and is essential for MTOR activation
  • recently identifed as a negative regulator of Rag GTPases (RRAGA, RRAGB, RRAGC, RRAGD)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS