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FLASH GENE
Symbol RRAGB contributors: mct - updated : 11-10-2014
HGNC name Ras-related GTP binding B
HGNC id 19901
Location Xp11.21      Physical location : 55.744.109 - 55.785.206
Synonym name GTP-binding protein ragB
Synonym symbol(s) RAGB
DNA
TYPE functioning gene
STRUCTURE 41.08 kb     11 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
FLJ20506 Xp11.22 hypothetical protein FLJ20506 PRKWNK3 Xp11.23-p11.21 protein kinase, lysine deficient 3 DT1P1A10 Xp11.22 hypothetical protein DT1P1A10 FGD1 Xp11.21 faciogenital dysplasia (Aarskog-Scott syndrome) FLJ10613 Xp11.22 hypothetical protein FLJ10613 LOC392473 X similar to dJ834A16.1 (similar to PGAM) UNQ6369 Xp11.22 ITI-like protein MAGED2 Xp11.2 melanoma antigen, family D, 2 TRO Xp11.22-p11.21 trophinin PFKFB1 Xp11.21 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 APEX2 Xp11.22 APEX nuclease (apurinic/apyrimidinic endonuclease) 2 ALAS2 Xp11.21 aminolevulinate, delta-, synthase 2 (sideroblastic/hypochromic anemia) LOC389860 X similar to PAGE-5 protein LOC203569 Xp11.22 similar to PAGE-5 protein LOC90736 Xp11.22 hypothetical protein BC000919 PAGE-5 Xp11.22 PAGE-5 protein LOC139793 Xp11.22 similar to XAGE-5 protein MAGEH1 Xp11.22 APR-1 protein LOC158880 LOC392474 X similar to hypothetical protein MGC21658 Xp11.22 similar to Forkhead box protein N4 LOC392475 X similar to XAGE-5 protein RRAGB Xp11.21 Ras-related GTP binding B LOC392476 X similar to Got2-prov protein KLF8 Xp11.21 Kruppel-like factor 8 UBQLN2 Xp11.23-p11.1 ubiquilin 2 LOC389861 X LOC389861 LOC169981 Xp11.22 hypothetical protein LOC169981 SPIN2 Xp11.23-p11.21 hypothetical protein LOC169981 FLJ31204 Xp11.21 hypothetical protein FLJ31204
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
10 splicing 2133 - 346 - 1995 7499430
RAGBs
11 splicing 2217 43 374 brain 1995 7499430
  • insertion of 28 codons between PM2 and PM3
  • RAGBl
  • EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineadrenal gland    
    Lymphoid/Immunespleen    
     thymus    
    Urinarykidney    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to murine LOC245670
    homolog to rattus Ragb
    Homologene
    FAMILY Ras family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,lysosome
    intracellular,nucleus
    basic FUNCTION
  • GTPase activity
  • do not directly stimulate the kinase activity of MTOR, but, like amino acids, promote the intracellular localization of MTOR to a compartment that also contains its activator RHEB
  • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    GTP binding
    protein
  • bind raptor and mediate amino acid signaling to MTOR
  • a complex encoded by the LAMTOR1, LAMTOR2, LAMTOR3 genes, which we term Ragulator, interacts with the RRAGA, RRAGB, RRAGC, RRAGD, recruits them to lysosomes, and is essential for MTOR activation
  • recently identifed as a negative regulator of Rag GTPases (RRAGA, RRAGB, RRAGC, RRAGD)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS