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FLASH GENE

Symbol

RPS7

contributors: mct - updated : 11-01-2023

HGNC name	ribosomal protein S7
HGNC id	10440

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	DBA8 Diamond-Blackfan anemia 8
Location	2p25.3      Physical location : 3.622.852 - 3.628.508
Synonym name	40S ribosomal protein S7E
EC.number	3.6.5.3

DNA

TYPE	functioning gene
STRUCTURE	5.66 kb     7 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001011 7 - 745 NP_001002 22 194 - 2007 17310983

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       moderately Hearing/Equilibrium ear       moderately

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow     highly

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text	predominantly in umbilical cord

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

conjugated

Other

mono polymer

complex

HOMOLOGY

interspecies	homolog to rattus Rps7 (100 pc)
	homolog to murine Rps7 (100 pc)

Homologene

FAMILY

ribosomal protein S7e family

CATEGORY

RNA associated

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic,ribosome
	intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
	intracellular,nucleus,nucleolus
text	SRY, RPS7 and RPL13A were co-localized in nuclear speckles

basic FUNCTION	being a structural constituent of ribosome
	acting as a modulator of p53-MDM2 interaction
	having an essential role for proliferation in all cells (Robledo 2008)
	functions as both effector and affector of MDM2 to ensure a proper cellular response to different stress signals
	novel function of RPS7 in control of GADD45A stabilization under both basal and stress conditions
	suppresses ovarian tumorigenesis and metastasis through PI3K/AKT and MAPK signal pathways

CELLULAR PROCESS

protein, translation/synthesis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component	small ribosomal subunit
	acetylation

INTERACTION

DNA

RNA

binding

small molecule

protein	binding to IPO9 with high affinity
	MDM2 ubiquitination of RPSS7 is involved in sustaining the TP53 response
	RPS7 (ribosomal protein S7) and RPL13a (ribosomal protein L13a) interact with the HMG (high-mobility group) box domain of SRY
	MDM2-binding partner, interacting with and stabilizing GADD45A through preventing the ubiquitination and degradation of GADD45A mediated by MDM2

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

DBA8

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	may be used as a potential marker for diagnosis and treatment of ovarian cancer
Therapy target

ANIMAL & CELL MODELS