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FLASH GENE
Symbol RPS6KC1 contributors: - updated : 30-08-2007
HGNC name ribosomal protein S6 kinase, 52kDa, polypeptide 1
HGNC id 10439
Location 1q41      Physical location : 213.224.587 - 213.446.807
Synonym name sphingosine kinase-1 (SPHK1)-binding protein
Synonym symbol(s) RPK118, humS6PKh1
DNA
TYPE functioning gene
STRUCTURE 222.00 kb     15 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Map cen - D12S85 - RPS6KC1 - D12S1635 - qter
Authors Zhang (99)
Physical map
LOC388733 1 similar to 40S ribosomal protein S25 LOC388734 1 similar to Px19-like protein (25 kDa protein of relevant evolutionary and lymphoid interest) (PRELI) (CGI-106) (SBBI12) FLJ10876 1q32.3 hypothetical protein FLJ10876 TRAF5 1q32 TNF receptor-associated factor 5 MGC14801 1q32.3 hypothetical protein MGC14801 LOC391160 1 similar to ARP2/3 complex 21 kDa subunit (p21-ARC) (Actin-related protein 2/3 complex subunit 3) C1orf36 1q32.3 chromosome 1 open reading frame 36 SLC30A1 1q32-q41 solute carrier family 30 (zinc transporter), member 1 LOC127184 1q32.3 similar to Farnesyl pyrophosphate synthetase (FPP synthetase) (FPS) (Farnesyl diphosphate synthetase) NEK2 1q32.2-q41 NIMA (never in mitosis gene a)-related kinase 2 KIAA0205 1p36.13-q42.3 NIMA (never in mitosis gene a)-related kinase 2 DKFZP434B168 1p36.13-q42.3 DKFZP434B168 protein RAMP 1q32.1-q32.2 DKFZP434B168 protein PPP2R5A 1q41 protein phosphatase 2, regulatory subunit B (B56), alpha isoform FLJ10874 1q32.3 hypothetical protein FLJ10874 SPUF 1q32.3 secreted protein of unknown function ATF3 1q32.3 activating transcription factor 3 FLJ32796 1q32.3 hypothetical protein FLJ32796 LOC388735 1 LOC388735 SNFT 1q32.3 Jun dimerization protein p21SNFT DC8 1q41 DKFZP566O1646 protein LOC388736 1 similar to ribosomal protein S5; 40S ribosomal protein S5 LOC149643 1q32.3 hypothetical LOC149643 FLVCR 1q32.1-q32.2 hypothetical LOC149643 FLJ12505 1q32.3 hypothetical protein FLJ12505 LOC90806 1q32.3 similar to RIKEN cDNA 2610307I21 RPS6KC1 1q41 ribosomal protein S6 kinase, 52kDa, polypeptide 1 LOC391161 1 similar to ribosomal protein L31 PROX1 1q32.2-q32.3 prospero-related homeobox 1 SMYD2 1q32.3 SET and MYND domain containing 2 PTPN14 1q32.2 protein tyrosine phosphatase, non-receptor type 14 CENPF 1q32-q41 centromere protein F, 350/400ka (mitosin)
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrinepancreas    
Nervousbrain   highly
Reproductivemale systemtestis  highly
Respiratoryrespiratory tracttrachea  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone  highly
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a catalytic domain containing conserved residues of the Ser/Thr protein kinase family
  • a phox-like and MIT domain
  • pseudokinase 1 and 2 domains (pseudokinase 2 domain is responsible for SPHK1 binding)
  • HOMOLOGY
    Homologene
    FAMILY
  • SER/THR family of protein kinases
  • S6 kinase subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • ribosomal protein S6 kinase, not involved in vivo in the phosphorylation of RPS6, mediating protein synthesis initiation and elongation induced by hormones or growth factors
  • may be playing an essential regulatory role in protein synthesis during cell proliferation
  • involved in protein amino acid phosphorylation, intracellular signaling cascade
  • may be involved in transmitting sphingosin 1 phosphate-mediated signaling into the cell
  • CELLULAR PROCESS protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    ATP binding
    protein
  • RPS6 binding
  • binding to phosphatidylinositol 3-phosphate
  • PRDX3-binding protein that may be involved in transporting PRDX3 from the cytoplasm to its mitochondrial site of function or to other membrane structures via endosome trafficking
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS