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FLASH GENE
Symbol RPS6KB2 contributors: mct - updated : 27-10-2012
HGNC name ribosomal protein S6 kinase, 70kDa, polypeptide 2
HGNC id 10437
Location 11q13.3      Physical location : 67.195.934 - 67.202.878
Synonym symbol(s) KLS, P70-beta, P70-beta-1, P70-beta-2, S6K-beta2, S6K2, SRK, STK14B
EC.number 2.7.11.1
DNA
TYPE functioning gene
STRUCTURE 6.94 kb     15 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Map cen - CST6 - PYGM PYGM - D11S913 - FAU - ACTN3 - PC - PPP1CA - RPS6KB2 - GSTP1 - CCND1 - FGF4 - ALDH3B1 - D11S1337 - ALDH3B2 - D11S1314 - D11S4184 - D11S916 - qter
Authors Gene Map,LDB
Physical map
SYT12 11q12.2 synaptotagmin XII ARHD 11q14.3 ras homolog gene family, member D FBXL11 11q12.2 F-box and leucine-rich repeat protein 11 PRO1880 11q13.2-q13.4 F-box and leucine-rich repeat protein 11 ADRBK1 11q13.3 adrenergic, beta, receptor kinase 1 LOC338692 11q13.1 hypothetical protein LOC338692 SSH-3 11q13.1 slingshot 3 POLD4 11q13 polymerase (DNA-directed), delta 4 CLC 19q13.1 Charot-Leyden crystal protein RAD9A 11q13.1-q13.2 RAD9 homolog (S. pombe) PPP1CA 11q13.3 protein phosphatase 1, catalytic subunit, alpha isoform RPS6KB2 11q13.3 ribosomal protein S6 kinase, 70kDa, polypeptide 2 FLJ00332 11q13.1 FLJ00332 protein KIAA1394 11q13.1 KIAA1394 protein PTPRCAP 11q13 protein tyrosine phosphatase, receptor type, C-associated protein CORO1B 11q12.2 coronin, actin-binding protein, 1B LOC390212 11 similar to putative G-protein coupled receptor CABP4 11q13.1-q13.4 calcium binding protein 4 FLJ21749 11q13.1 hypothetical protein FLJ21749 AIP 11q13.3 aryl hydrocarbon receptor interacting protein PITPNM1 11q13 phosphatidylinositol transfer protein, membrane-associated 1 DOC-1R 11q13 tumor suppressor deleted in oral cancer-related 1 CABP2 11q13.1 calcium binding protein 2 GSTP1 11q13.3 glutathione S-transferase pi FLJ90834 11q13.1 hypothetical protein FLJ90834 NDUFV1 11q13 NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa LOC390213 11 similar to Double C2, gamma NUDT8 11q13.1 nudix (nucleoside diphosphate linked moiety X)-type motif 8 TBX10 11q13 T-box 10 ACY-3 11q13.1 aspartoacylase-3 ALDH3B2 11q13 aldehyde dehydrogenase 3 family, member B2 RPL37P2 11q13 ribosomal protein L37 pseudogene 2
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
15 - 1782 - 482 - 2011 21427355
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two non identical catalytic domains, respectively located in N and C terminal region
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • ribosomal protein S6 kinase, not involved in the phosphorylation of RPS6, mediating protein synthesis initiation and elongation induced by hormones or growth factors
  • may be playing an essential regulatory role in protein synthesis during cell proliferation
  • plays a role in IL3-dependent cell proliferation
  • RPS6KB2 but not RPS6KB1 mediates prosurvival/chemoresistance signalling
  • play important roles in the regulation of protein synthesis, cell growth and survival
  • in addition to phosphorylation, RPS6KB1, and RPS6KB2 are also targeted by lysine acetylation
  • promotes breast cancer cell survival via AKT1
  • RPS6KB1 and RPS6KB2, are important MTOR signaling effectors, but with a differential protein expression in human tissues
  • CELLULAR PROCESS protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    ATP binding
    protein
  • RPS6 binding
  • RPS6KB1/2 phosphorylate EIF3A to stimulate PAIP1-EIF3A interaction and consequent translation initiation
  • cell & other
    REGULATION
    activated by IL3 in the IL3-dependent Ba/F3 cell line and this is mediated by MTOR and its upstream activator PI-3K but not by the MAPK kinase/extracellular signal-regulated kinase pathway
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS