protein
| neurabin (neural tissue-specific F-actin binding protein) |
|
Protein phosphatase 2A, PP2A |
|
cap-binding complex, CBC |
|
regulatory associated protein of MTOR, complex 1 |
|
cell division cycle 2, CDC2 |
|
rapamycin (mTOR) |
|
tumor necrosis factor receptor-associated factor 4, TRAF4 |
|
S6K1 Aly/REF-like target, SKAR |
|
CoA synthase |
|
human telomerase reverse transcriptase, hTERT |
|
p-tau (S262 and S396/404) |
|
platelet-derived growth factor receptor, PDGFR |
|
protein kinase CK2 |
|
prefoldin chaperone C19orf2 |
|
ras-like without CAAX protein 1, ROC1 |
|
peptidylprolyl cis/trans isomerase, NIMA-interacting 1, PIN1 |
|
RICTOR is a direct target of the ribosomal protein S6 kinase-1 (RPS6KB1) |
|
attractive target downstream of MTOR for activation of glycolysis in PTEN-deficient cell |
|
is a novel substrate of PHLPP1 |
|
BCR-ABL potently activated RPS6KB1-dependent signaling and glycolysis |
|
PTPN11 is required for leucine-induced activation of RPS6KB1 in skeletal myoblasts |
|
PRKAA2 controls cardiac RPS6KB1 under normoxia and regulates EEF2 but not the MTOR-RPS6KB1 pathway during ischemia |
|
RPS6KB1 negatively regulates TLR-mediated signals by inhibiting MAP3K7 activity |
|
RPS6KB1/2 phosphorylate EIF3A to stimulate PAIP1-EIF3A interaction and consequent translation initiation |
|
MTOR activation inhibits eukaryotic translation initiation factor 4E-binding protein (EIF4EBP1) and activates ribosomal protein S6 kinase 1 (RPS6KB1), both of which stimulate translation |
|
molecularly, RPS6KB1 enhances MYC translation efficiency by modulating the phosphorylation of eukaryotic initiation factor EIF4B, which is critical to unwind its structured 5' untranslated region (5'UTR) |
| homozygous disruption of the Rps6kb1 gene does not affect viability or fertility of mice, but that it has a significant effect on animal growth, especially during embryogenesis | |
S6K1(-/-) mice are significantly smaller and S6K1(-/-)/S6K2(-/-) mice show a sharp reduction in viability due to perinatal lethality |
|
mice deficient for S6 Kinase 1 are hypoinsulinaemic, glucose intolerant and have reduced beta-cell mass but S6K1-deficient mice are protected against obesity owing to enhanced beta-oxidation |
|
mice deleted for S6K1 have increased life span and are resistance to age-related pathologies |