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FLASH GENE

Symbol

RPS6KA5

contributors: mct/pgu - updated : 05-11-2020

HGNC name	ribosomal protein S6 kinase, 90kDa, polypeptide 5
HGNC id	10434

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	14q32.11      Physical location : 91.337.166 - 91.526.993
Synonym name	mitogen and stress activated protein kinase 1
Synonym symbol(s)	MSK1, MSPK1, RLPH, MGC1911, RLPK
EC.number	2.7.11.1

DNA

TYPE	functioning gene
STRUCTURE	212.78 kb     17 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

Map	cen - D14S81 - D14S961 - D14S291 - RPS6KA5 - D14S995 - D14S593 - D14S265 - D14S65 - qter
Authors	Jiang (99)

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001322232 16 - 26610 NP_001309161 - 729 - 2019 30679314 NM_001322228 16 - 26721 NP_001309157 - 766 - 2019 30679314 NM_001322236 16 - 26745 NP_001309165 - 774 - 2019 30679314 NM_001322231 16 - 26725 NP_001309160 - 563 - 2019 30679314 NM_001322233 16 - 26667 NP_001309162 - 748 - 2019 30679314 NM_001322229 17 - 26808 NP_001309158 - 795 - 2019 30679314 NM_004755 17 - 26829 NP_004746 - 802 - 2019 30679314 NM_001322230 18 - 27016 NP_001309159 - 535 - 2019 30679314 NM_001322234 17 - 26866 NP_001309163 - 610 - 2019 30679314 NM_001322227 18 - 26989 NP_001309156 - 521 - 2019 30679314 NM_001322235 18 - 26969 NP_001309164 - 723 - 2019 30679314 NM_001322238 15 - 26335 NP_001309167 - 583 - 2019 30679314 NM_001322237 17 - 26626 NP_001309166 - 723 - 2019 30679314

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Hearing/Equilibrium ear inner cochlea   highly Nervous brain       predominantly Reproductive female system placenta     highly Respiratory respiratory tract larynx     highly

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	two non identical conserved kinase catalytic domains
	an APE motif
	a dual kinase domain

HOMOLOGY

Homologene

FAMILY

ser/thr protein kinase family, S6 kinase subfamily

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,nucleus,nucleoplasm
text	nucleus, predominantly
	cytoplasm, partially

basic FUNCTION	ribosomal protein S6 kinase, serine/threonine kinase, non receptor type
	may be mediating the growth factor and stress-induced activation of CREB
	playing an essential role in the control of RELA transcriptional activity in response to TNF
	acting downstream of the ERK1/2 (extracellular-signal-regulated kinase 1/2) and p38 MAPK (mitogen-activated protein kinase) signalling pathways in cells (Mccoy 2007) directly repressing transcription via phosphorylation of ser-1 of histone H2A

CELLULAR PROCESS

protein, translation/synthesis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

complex with either ERK1 or ERK2 in quiescent cells which transiently dissociates following mitogenic stimulation

INTERACTION

DNA

RNA

small molecule
	ATP binding

protein	RPS6 binding
	phosphorylate the transcription factors CREB (cAMP-response-element-binding protein) and ATF1, and the chromatin proteins histone H3 and HMGN1 in response to either mitogenic stimulation or cellular stress
	CSNK2B is a binding and regulatory partner for RPS6KA5
	KMT2A/MLL1 is required for the genomic targeting of RPS6KA5, but not vice versa
	role of RPS6KA5 in the induction of NFKB1 by the chemokine CX3CL1 in microglial cells

cell & other

REGULATION

activated by

the activation of the ERK1/2 or p38 MAPK cascades but does not appear to require additional signalling inputs

Other

regulation controlled by multiple phosphorylation sites

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS