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FLASH GENE
Symbol RPS6KA5 contributors: mct/pgu - updated : 05-01-2007
HGNC name ribosomal protein S6 kinase, 90kDa, polypeptide 5
HGNC id 10434
Location 14q32.12      Physical location : 91.337.166 - 91.526.993
Synonym name mitogen and stress activated protein kinase 1
Synonym symbol(s) MSK1, MSPK1, RLPH, MGC1911, RLPK
DNA
TYPE functioning gene
STRUCTURE 189.00 kb     17 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Map cen - D14S81 - D14S961 - D14S291 - RPS6KA5 - D14S995 - D14S593 - D14S265 - D14S65 - qter
Authors Jiang (99)
Physical map
CHES1 14q24.3-q31 checkpoint suppressor 1 C14orf116 14q31.3 chromosome 14 open reading frame 116 CAP2P1 14 CAP, adenylate cyclase-associated protein, 2 (yeast) pseudogene 1 PRO1768 14q32.11 PRO1768 protein CHORDC2P 14 cysteine and histidine-rich domain (CHORD)-containing 2 pseudogene C14orf143 14q32.11 chromosome 14 open reading frame 143 TDP1 14q32.11 tyrosyl-DNA phosphodiesterase 1 KCNK13 14q24.1-q24.3 potassium channel, subfamily K, member 13 GLRXP2 14q32.13-q32.2 glutaredoxin pseudogene 2 PSMC1 19p13.3 proteasome (prosome, macropain) 26S subunit, ATPase, 1 C14orf102 14q32.11 chromosome 14 open reading frame 102 RPL21P11 14q32.11 ribosomal protein L21 pseudogene 11 CALM1 14q24-q31 calmodulin 1 (phosphorylase kinase, delta) TTC7L1 14q32.12 tetratricopeptide repeat domain 7 like 1 RPS18P2 14 ribosomal protein S18 pseudogene 2 LOC283588 14q32.12 hypothetical protein LOC283588 RPS6KA5 14q31-q32.1 ribosomal protein S6 kinase, 90kDa, polypeptide 5 C14orf159 14q32.12 chromosome 14 open reading frame 159 GPR68 14q31 G protein-coupled receptor 68 KIAA1509 14q32.12 KIAA1509 LOC388005 14 similar to RIKEN cDNA 0610010D24 KIAA2010 14q32.12 KIAA2010 C14orf161 14q32.12 chromosome 14 open reading frame 161 MTAC2D1 14q32.12 membrane targeting (tandem) C2 domain containing 1 FBLN5 14q32.1 fibulin 5 TRIP11 14q31-q32 thyroid hormone receptor interactor 11 PTMAP7 14 prothymosin, alpha pseudogene 7 MJD 14q24.4-q32.1 Machado-Joseph disease (spinocerebellar ataxia 3, olivopontocerebellar ataxia 3, autosomal dominant, ataxin 3) NDUFB1 14q31.3 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7kDa CPSF2 14q31.3 cleavage and polyadenylation specific factor 2, 100kDa SLC24A4 14q32.12-q32.13 solute carrier family 24 (sodium/potassium/calcium exchanger), member 4 RIN3 14q32.13 Ras and Rab interactor 3
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Hearing/Equilibriumearinnercochlea highly
Nervousbrain   predominantly
Reproductivefemale systemplacenta  highly
Respiratoryrespiratory tractlarynx  highly
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two non identical conserved kinase catalytic domains
  • an APE motif
  • a dual kinase domain
  • HOMOLOGY
    Homologene
    FAMILY ser/thr protein kinase family, S6 kinase subfamily
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    text
  • nucleus, predominantly
  • cytoplasm, partially
  • basic FUNCTION
  • ribosomal protein S6 kinase, serine/threonine kinase, non receptor type
  • may be mediating the growth factor and stress-induced activation of CREB
  • playing an essential role in the control of RELA transcriptional activity in response to TNF
  • acting downstream of the ERK1/2 (extracellular-signal-regulated kinase 1/2) and p38 MAPK (mitogen-activated protein kinase) signalling pathways in cells (Mccoy 2007) directly repressing transcription via phosphorylation of ser-1 of histone H2A
  • CELLULAR PROCESS protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component complex with either ERK1 or ERK2 in quiescent cells which transiently dissociates following mitogenic stimulation
    INTERACTION
    DNA
    RNA
    small molecule
    ATP binding
    protein
  • RPS6 binding
  • phosphorylate the transcription factors CREB (cAMP-response-element-binding protein) and ATF1, and the chromatin proteins histone H3 and HMGN1 in response to either mitogenic stimulation or cellular stress 7)
  • CSNK2B is a binding and regulatory partner for RPS6KA5
  • cell & other
    REGULATION
    activated by the activation of the ERK1/2 or p38 MAPK cascades but does not appear to require additional signalling inputs
    Other regulation controlled by multiple phosphorylation sites
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS