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FLASH GENE

Symbol

RPS6KA4

contributors: np/ - updated : 04-07-2007

HGNC name	ribosomal protein S6 kinase, 90kDa, polypeptide 4
HGNC id	10433

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	11q13.1      Physical location : 64.126.624 - 64.139.686
Synonym name	nuclear mitogen- and stress-activated protein kinase 2
	ribosomal protein S6 kinase alpha 4
Synonym symbol(s)	MSK2, RSKB, RSK-B, S6K-alpha-4
EC.number	2.7.11.1

DNA

TYPE	functioning gene
STRUCTURE	13.06 kb     17 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001006944 17 - 3131 NP_001006945 - 766 - - NM_003942 17 - 3149 NP_003933 - 772 - -

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic spleen         Endocrine pancreas         Nervous brain         Reproductive male system prostate

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic         Connective bone       Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine   Lymphoid

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic leukocyte

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	two protein kinase domains
	one N terminal,the other C like, calcium-calmodulin like at C terminus

HOMOLOGY

Homologene

FAMILY	protein kinase superfamily
	ribosdomal protein S6 kinase(RSK) family

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION

implicated in the activation of the mitogen- activated kinase cascade

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

substrate for p38 alpha MAPK phosphorylating cAMP response element binding protein CREB and c Fos peptides

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS