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FLASH GENE
Symbol RPS6KA4 contributors: np/ - updated : 04-07-2007
HGNC name ribosomal protein S6 kinase, 90kDa, polypeptide 4
HGNC id 10433
Location 11q13.1      Physical location : 64.126.624 - 64.139.686
Synonym name
  • nuclear mitogen- and stress-activated protein kinase 2
  • ribosomal protein S6 kinase alpha 4
  • Synonym symbol(s) MSK2, RSKB, RSK-B, S6K-alpha-4
    EC.number 2.7.11.1
    DNA
    TYPE functioning gene
    STRUCTURE 13.06 kb     17 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC387776 11 LOC387776 FLRT1 11q12-q13 fibronectin leucine rich transmembrane protein 1 STIP1 11q13.2 stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing protein) URP2 11q13.1 UNC-112 related protein 2 short form MGC11134 11q13.1 tRNA splicing 2' phosphotransferase 1 MGC13045 11q13.1 hypothetical protein MGC13045 DNAJC4 11q13 DnaJ (Hsp40) homolog, subfamily C, member 4 VEGFB 11q13 vascular endothelial growth factor B FKBP2 11q13.1 FK506 binding protein 2, 13kDa PPP1R14B 11q13 protein phosphatase 1, regulatory (inhibitor) subunit 14B PLCB3 11q13.1-q13.2 phospholipase C, beta 3 (phosphatidylinositol-specific) BAD 11q12.3 BCL2-antagonist of cell death C11ORF4 11cen-q22.3 chromosome 11 hypothetical protein ORF4 KCNK4 11q13 potassium channel, subfamily K, member 4 ESRRA 11q12-q13 estrogen-related receptor alpha HSPC152 11q13.1 hypothetical protein HSPC152 PRDX5 11q13.1 peroxiredoxin 5 FLJ37970 11q12.3 hypothetical protein FLJ37970 RPS6KA4 11q11-q13 ribosomal protein S6 kinase, 90kDa, polypeptide 4 LOC387777 11 LOC387777 FLJ37045 11q13.1 hypothetical protein FLJ37045 SLC22A11 11q13.1 solute carrier family 22 (organic anion/cation transporter), member 11 SLC22A12 11q13.1 solute carrier family 22 (organic anion/cation transporter), member 12 NRXN2 11q13.2 neurexin 2
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    17 - 3131 - 766 - -
    17 - 3149 - 772 - -
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen    
    Endocrinepancreas    
    Nervousbrain    
    Reproductivemale systemprostate   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoietic    
    Connectivebone   
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticleukocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two protein kinase domains
  • one N terminal,the other C like, calcium-calmodulin like at C terminus
  • HOMOLOGY
    Homologene
    FAMILY
  • protein kinase superfamily
  • ribosdomal protein S6 kinase(RSK) family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • implicated in the activation of the mitogen- activated kinase cascade
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • substrate for p38 alpha MAPK phosphorylating cAMP response element binding protein CREB and c Fos peptides
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS