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FLASH GENE
Symbol RPS6KA2 contributors: mct - updated : 24-03-2012
HGNC name ribosomal protein S6 kinase, 90kDa, polypeptide 2
HGNC id 10431
Location 6q27      Physical location : 166.822.853 - 167.275.771
Synonym name
  • MAPKAP kinase 1c
  • ribosomal S6 kinase 3
  • MAPK-activated protein kinase 1c
  • ribosomal protein S6 kinase alpha 2
  • Synonym symbol(s) RSK3, p90rsk,
    EC.number 2.7.11.1
    DNA
    TYPE functioning gene
    STRUCTURE 452.92 kb     21 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    C6orf118 6q27 chromosome 6 open reading frame 118 PDE10A 6q26 phosphodiesterase 10A LOC346085 6q27 similar to Glyceraldehyde 3-phosphate dehydrogenase, liver (GAPDH) T 6q27 T, brachyury homolog (mouse) MGC35308 6q27 hypothetical protein MGC35308 C6orf83 6q27 chromosome 6 open reading frame 83 BRP44L 6q27 brain protein 44-like RPS6KA2 6q27 ribosomal protein S6 kinase, 90kDa, polypeptide 2 RNASET2 6q27 ribonuclease T2 FGFR1OP 6q27 FGFR1 oncogene partner CCR6 6q27 chemokine (C-C motif) receptor 6 GPR31 6q27 G protein-coupled receptor 31 LOC389448 6 similar to T-complex protein 10A homolog LOC391986 6 similar to unc-93 homolog A UNC93A 6q27 unc-93 homolog A (C. elegans) C6orf104 LOC389449 6 LOC389449 TCP10 6q26 t-complex 10 (mouse) LOC391987 6 similar to Serine palmitoyltransferase 2 (Long chain base biosynthesis protein 2) (LCB 2) (Serine-palmitoyl-CoA transferase 2) (SPT 2) C6orf123 6q27 chromosome 6 open reading frame 123 MLLT4 6q27 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 LOC202546 6q27 hypothetical LOC202546 C6orf54 6q27 chromosome 6 open reading frame 54 KIF25 6q27 kinesin family member 25 FRMD1 6q27 FERM domain containing 1 LOC389450 6 LOC389450 LOC154323 6q27 hypothetical LOC154323 MGC33437 6q27 meningioma expressed antigen 6 (coiled-coil proline-rich) pseudogene
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    22 - 5735 90 741 - 2011 21527514
    21 - 5817 - 733 - 2011 21527514
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Reproductivefemale systemovary    Homo sapiens
    Respiratorylung   predominantly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductiveepithelial cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    two non identical catalytic domains,respectively located in N and C terminal region
    HOMOLOGY
    Homologene
    FAMILY growth factor regulated serine/threonine kinase family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,ribosome
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • ribosomal S6 kinase,serine/threonine kinase,non receptor type,not involved in vivo in the phosphorylation of RPS6,mediating protein synthesis initiation and elongation induced by hormones or growth factors
  • maybe playing an essentilal regulatory role in protein synthesis during cell proliferation
  • putative tumour suppressor gene at 6q27 in sporadic epithelial ovarian cancer
  • critical serine/threonine kinase for the regulation of cell transformation
  • key regulator for cell transformation induced by tumor promoters such as EGF and TPA
  • negatively regulates axon elongation via the MAPK pathway
  • important in diverse cellular processes including gene expression, cell proliferation, and survival
  • dispensable for BCR-ABL-induced myeloid leukemia, but may be required for pathogenesis and lineage determination in FLT3-ITD-induced hematopoietic transformation
  • CELLULAR PROCESS protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    ATP binding
    protein
  • RPS6 binding
  • interacting with MAPK7
  • binding to PDZ domain proteins and phosphorylation of these proteins or their binding partners regulates excitatory synaptic transmission
  • cell & other
    REGULATION
    Phosphorylated by MAPK7 (phosphorylation by MAPK7 causes its activation, indicating that RPS6KA2 is a substrate of MAPK7)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS