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Symbol RPS6KA1 contributors: mct/ - updated : 29-05-2013
HGNC name ribosomal protein S6 kinase, 90kDa, polypeptide 1
HGNC id 10430
Location 1p36.11      Physical location : 26.856.248 - 26.901.520
Synonym name
  • MAP kinase-activated protein kinase 1a
  • dJ590P13.1 (ribosomal protein S6 kinase, 90kD, polypeptide 1)
  • Synonym symbol(s) RSK, RSK1, MAPKAPK1A, HU-1, p90-RSK 1
    EC.number 2.7.11.1
    DNA
    TYPE functioning gene
    STRUCTURE 45.27 kb     22 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status tentative : very preliminary evidence
    Map pter - D1S478 - D1S2864 - RH - D1S2749 - RPA2 - D1S449 - cen
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    22 - 3199 - 735 - 2006 16738324
    21 - 3112 - 744 - 2006 16738324
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen   highly
    Nervousbrainhindbraincerebellum  
    Respiratorylung    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Lymphoid    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two non identical catalytic domains, respectively located in N and C terminal region
  • C-terminal kinase domain (CTKD) receiving signal from ERK1/2 and adopts an autoinhibitory mechanism
  • HOMOLOGY
    Homologene
    FAMILY
  • protein kinase superfamily
  • AGC Ser/Thr protein kinase family
  • S6 kinase subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • ribosomal protein S6 kinase, serine/threonine kinase, non receptor type, not involved in vivo in the phosphorylation of RPS6, mediating protein synthesis initiation and elongation induced by hormones or growth factors
  • may be playing an essentilal regulatory role in protein synthesis during cell proliferation
  • modulates interleukin-1beta-induced persistent activation of NF-kappaB through phosphorylation of NFKBIB
  • associates with and phosphorylates NOS1 on Ser847 following mitogen stimulation, suggesting a novel role for RPS6KA1 in the regulation of nitric oxide function in brain
  • ERK-RPS6KA1 activation by growth factors delays G2/M transition and this might be required to maintain genomic integrity during growth factor stimulation
  • facilitates nuclear CHEK1 accumulation through CHEK1-Ser-280 phosphorylation and this pathway plays an important role in the preparation for monitoring genetic stability during cell proliferation
  • major downstream effector of the kinase mammalian target of rapamycin, in leucine deprivation stimulation of energy expenditure
  • CELLULAR PROCESS protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
  • ATP binding
  • protein
  • RPS6 binding
  • interaction between PRKACA and RPS6KA1 required the phosphorylation of Ser-732 in the C terminus of RPS6KA1
  • critical role for the activated RPS6SKA1 in IFNL1 signaling
  • inhibits by phosphorylation OSTF1, a negative regulator of cell motility
  • MTOR influences cellular growth by phosphorylating RPS6KA1, a serine/threonine kinase that regulates S6 ribosomal protein and other members of the translational machinery
  • is a part of a negative-feedback loop that restricts GAB2-dependent epithelial cell motility
  • regulates anchorage-independent growth through transcriptional regulation of factors that modulate cell survival, including ING3, CKAP2, and PTK6
  • cell & other
    REGULATION
    Other on S221 is important for its dissociation from the type PRKACA in the cytoplasm and RSP6KA1 contains a bipartite nuclear localization sequence that is necessary for its nuclear entry
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS